Evidence map›Paper›PMID 32082373›Full record

ArticleInternational journal of endocrinology2019

Gender-Specific Differences on the Association of Hypertension with Subclinical Thyroid Dysfunction.

Jingkai Zhang, Chao Huang, Zhaowei Meng, Yaguang Fan, Qing Yang, Wenjuan Zhang, Yuxia Gao, Zhenwen Yang, Heng Cai, Bo Bian and 12 more

Open access · goldAbstract read
In one paragraph

Article in International journal of endocrinology, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.8field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 21 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

22 authors at 3 institutions in 2 countries.

Jingkai ZhangDepartment of Ophthalmology, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0003-4268-532X
Chao HuangHull York Medical School, University of Hull, Hull, UK.
Zhaowei MengDepartment of Nuclear Medicine, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-4478-878X
Yaguang FanTianjin Key Laboratory of Lung Cancer Metastasis and Tumor Microenvironment, Tianjin Lung Cancer Institute, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0001-7246-8858
Qing YangDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0001-5481-9079
Wenjuan ZhangDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Yuxia GaoDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-9246-320X
Zhenwen YangDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Heng CaiDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Bo BianDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-0264-5473
Yongle LiDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Xuefang YuDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Xin DuDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Shaopeng XuDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Jing NieDepartment of Cardiology, Tianjin Medical University General Hospital, Tianjin, China.
Ming LiuDepartment of Endocrinology and Metabolism, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0003-2665-4072
Jinhong SunDepartment of Health Management, Tianjin Medical University General Hospital, Tianjin, China.
Qing ZhangDepartment of Health Management, Tianjin Medical University General Hospital, Tianjin, China.
Ying GaoDepartment of Health Management, Tianjin Medical University General Hospital, Tianjin, China.
Kun SongDepartment of Health Management, Tianjin Medical University General Hospital, Tianjin, China.ORCID https://orcid.org/0000-0002-1564-9916
Xing WangDepartment of Health Management, Tianjin Medical University General Hospital, Tianjin, China.
Li ZhaoDepartment of Biochemistry and Molecular Biology, School of Basic Medical Sciences, Tianjin Medical University, Tianjin, China.ORCID https://orcid.org/0000-0002-1378-7434
Tianjin Medical University General Hospital · CNTianjin Medical University · CNUniversity of Hull · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveBoth hypertension and subclinical thyroid dysfunction (STD) have high prevalence and clinical importance, but their relationship is still a matter of debate. We aimed to explore gender-specific difference on the association between hypertension and STD in Chinese.

methodsWe recruited 13,380 ostensible healthy participants (8,237 men and 5,143 women). The associations between hypertension and STD were analyzed on a gender-based setting after dividing STD into subclinical hypothyroidism, subclinical hyperthyroidism and further subgrouped euthyroidism. Crude and adjusted odds ratios of STD for hypertension were analyzed by binary logistic regression.

resultsAn increasing trend of hypertension prevalence was found along with aging in both genders. Yet, higher male hypertension prevalence was found until 65 years, and then it intersected with female hypertension prevalence. Women had significantly higher propensity for STD than men. Yet, in elderly participants, this gender-specific difference became less obvious. We displayed detrimental effects for subclinical hypothyroidism in both genders after multiple-covariate adjustments, yet no such effects were shown for subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism were more likely to be associated with hypertension than males, and the corresponding odds ratios were 1.619 (

conclusionWe demonstrate that hypertension is associated with subclinical hypothyroidism, but not with subclinical hyperthyroidism. Moreover, females with subclinical hypothyroidism are more likely to be associated with hypertension than males.

Identifiers

PMID32082373
PMCPMC7012202
OpenAlexW2998377182

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.