Evidence map›Paper›PMID 32082327›Full record

ArticleFrontiers in immunology2020

NK Cell Priming From Endogenous Homeostatic Signals Is Modulated by CIS.

Rebecca B Delconte, Geoffrey Guittard, Wilford Goh, Soroor Hediyeh-Zadeh, Robert J Hennessy, Jai Rautela, Melissa J Davis, Fernando Souza-Fonseca-Guimaraes, Jacques A Nunès, Nicholas D Huntington

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
2.1field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 39 citations in OpenAlex.

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  13. Natural Killer Cell-Based Immunotherapy against Glioblastoma.International journal of molecular sciences · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 5 institutions in 2 countries.

Rebecca B DelconteDivision of Molecular Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Geoffrey GuittardCentre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille Université, Marseille, France.
Wilford GohDivision of Molecular Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Soroor Hediyeh-ZadehDepartment of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.
Robert J HennessyDivision of Molecular Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Jai RautelaoNKo-Innate Pty Ltd., Melbourne, VIC, Australia.
Melissa J DavisDepartment of Medical Biology, Faculty of Medicine, Dentistry and Health Sciences, University of Melbourne, Melbourne, VIC, Australia.
Fernando Souza-Fonseca-GuimaraesUniversity of Queensland Diamantina Institute, Translational Research Institute, University of Queensland, Brisbane, QLD, Australia.
Jacques A NunèsCentre de Recherche en Cancérologie de Marseille, CRCM, Immunity and Cancer Team, Institut Paoli-Calmettes, Inserm, CNRS, Aix Marseille Université, Marseille, France.
Nicholas D HuntingtonDivision of Molecular Immunology, The Walter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.
Walter and Eliza Hall Institute of Medical Research · AUAustralian Regenerative Medicine Institute · AUCentre de Recherche en Cancérologie de Marseille · FRInserm · FRTranslational Research Institute · AU

Funding

EPA EP-C-15-008
6 · The paper itself

Abstract

Natural killer (NK) cell activation is controlled by a balance of activating and inhibitory signals and cytokines such as IL-15. We previously identified cytokine-inducible SH2-containing protein (CIS) as a negative regulator of IL-15 signaling in NK cells under inflammatory conditions. While the functional effect of

Indexed as

AnimalsCell DifferentiationHomeostasisInterleukin-15Killer Cells, NaturalLymphocyte ActivationMiceMice, Inbred C57BLMice, KnockoutSuppressor of Cytokine Signaling ProteinsInterleukin-15Suppressor of Cytokine Signaling ProteinsCISHomeostasisIL-15NK cellpriming

Identifiers

PMID32082327
PMCPMC7005222
OpenAlexW3004133899

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.