ArticleFrontiers in immunology2020
Molecular Signatures of Neuroinflammation Induced by αSynuclein Aggregates in Microglial Cells.
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In one paragraph
Article in Frontiers in immunology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 60 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
60citing papers in PubMed, 1 pooled it
4.8field-weighted citation impact, top 4% of its field
What it found
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Who cites it
60 citing papers in PubMed, 1 synthesis or guideline pooled it, 85 citations in OpenAlex.
- Pre-clinical Studies Identifying Molecular Pathways of Neuroinflammation in Parkinson's Disease: A Systematic Review.Frontiers in aging neuroscience · 2022Pooled it
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- Interaction of coronavirus E protein with BRD2 plays important regulatory roles in viral replication and induction of pro-inflammatory response.Journal of virology · 2026Article
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- Simulated microgravity affects neuronal synaptic plasticity by regulating microglial pro-inflammatory activation.NPJ microgravity · 2026Article
- Role of Microglial Dysfunction in Parkinson's Disease: From Multifactorial Causes to Neurodegeneration.Neuroscience bulletin · 2026Review
- Reprogramming brain-resident macrophages: from disease drivers to therapeutic allies in neurological disorders.Frontiers in cellular neuroscience · 2026Review
- Roles of Microglia in Synaptogenesis, Synaptic Pruning, and Synaptic Plasticity in Physiological Conditions and Central Nervous System Disorders.Current neuropharmacology · 2026Review
- Cardiolipin and mitochondrial membrane integrity in neurodegeneration: insights from α-synuclein-driven Parkinson's disease.Acta neuropathologica communications · 2025Review
- Summarizing the Role of Selected Adipokines in Parkinson's Disease: What Is Known About Leptin, Adiponectin, Resistin, Visfatin, and Progranulin in Neurodegeneration?Molecules (Basel, Switzerland) · 2025Review
- The Interplay Between CBInternational journal of molecular sciences · 2025Article
- PGRN as an emerging regulator of lipid metabolism in neurodegenerative diseases.Communications biology · 2025Review
- Intermittent fasting reduces alpha-synuclein pathology and functional decline in a mouse model of Parkinson's disease.Nature communications · 2025Article
- Biotin mitigates the development of manganese-induced, Parkinson's disease-related neurotoxicity inScience signaling · 2025Article
- The effect of AKT inhibition in α-synuclein-dependent neurodegeneration.Frontiers in molecular neuroscience · 2025Article
- Regulation of TAR DNA binding protein 43 (TDP-43) homeostasis by cytosolic DNA accumulation.The Journal of biological chemistry · 2024Article
- Comparative Proteomics Highlights that GenX Exposure Leads to Metabolic Defects and Inflammation in Astrocytes.Environmental science & technology · 2024Article
- Progressive Supranuclear Palsy Syndrome: An Overview.IBRO neuroscience reports · 2024Review
Corrections and comments
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Authors and funding
16 authors at 5 institutions in 1 country.
Souvarish SarkarDepartment of Pathology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Eric B DammerDepartment of Biochemistry, Emory University, Atlanta, GA, United States.
Emir MalovicDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Abby L OlsenDepartment of Neurology, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, United States.
Syed Ali RazaDepartment of Neurology, Emory University, Atlanta, GA, United States.
Tianwen GaoDepartment of Neurology, Emory University, Atlanta, GA, United States.
Hailian XiaoDepartment of Neurology, Emory University, Atlanta, GA, United States.
Danielle L OliverDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.
Duc DuongDepartment of Biochemistry, Emory University, Atlanta, GA, United States.
Valerie JoersDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.
Nicholas SeyfriedDepartment of Biochemistry, Emory University, Atlanta, GA, United States.
Meixiang HuangDepartment of Pharmacology and Chemical Biology, Emory University, Atlanta, GA, United States.
Thomas KukarDepartment of Neurology, Emory University, Atlanta, GA, United States.
Malú G TanseyDepartment of Neuroscience, University of Florida College of Medicine, Gainesville, FL, United States.
Anumantha G KanthasamyDepartment of Biomedical Sciences, Iowa State University, Ames, IA, United States.
Srikant RangarajuDepartment of Neurology, Emory University, Atlanta, GA, United States.
Emory University · USIowa State University · USUniversity of Florida · USFlorida College · USHarvard University · US
Funding
Yerkes National Primate Research Center Role of type-I IFN in regulating COVID-19 induced inflammation and pathogenesisP51OD011132 · OD · EMORY UNIVERSITY · PI Joon Sup Lee · 2012 to 2026
$167.0MThe Emory Alzheimer's Disease CenterP50AG025688 · NIA · EMORY UNIVERSITY · PI WALKER, LARY C · 2005 to 2019
$25.7MENNCF - Viral Vector CoreP30NS055077 · NINDS · EMORY UNIVERSITY · PI GEARING, MARLA · 2008 to 2018
$6.8MUdall Parkinson's Disease Research Center at Emory UniversityP50NS098685 · NINDS · EMORY UNIVERSITY · PI SMITH, YOLAND · 2016 to 2020
$6.7MTRAINING IN TRANSLATIONAL RESEARCH IN NEUROLOGYT32NS007480 · NINDS · EMORY UNIVERSITY · PI LEVEY, ALLAN I · 2000 to 2020
$4.5MInflammation and Renin-Angiotensin System Dysfunction as risk factors for ADRF1AG051514 · NIA · EMORY UNIVERSITY · PI NORRIS, CHRISTOPHER MARK, WALKER, LARY C · 2015 to 2017
$3.6MTargeting Kv1.3 potassium channels for neuro-immunomodulation in Alzheimer's DiseaseR01NS114130 · NINDS · YALE UNIVERSITY · PI RANGARAJU, SRIKANT · 2020 to 2024
$3.1MProtein Aggregation and Inflammasome Signaling in Manganese Neurotoxicity.R01ES026892 · NIEHS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2016 to 2020
$2.0MMolecular mechanisms of Progranulin in NeurodegenerationR01NS105971 · NINDS · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2018 to 2022
$1.9MNeuroinflammation and microglial Kv1.3 in Parkinsons diseaseR01NS100090 · NINDS · UNIVERSITY OF GEORGIA · PI KANTHASAMY, ANUMANTHA GOUNDER · 2017 to 2021
$1.9MRole of HLA/MHCII in Parkinson's Disease PathogenesisR01NS092122 · NINDS · EMORY UNIVERSITY · PI BOSS, JEREMY M., TANSEY, MARIA DE LOURDES GAMEZ · 2015 to 2019
$1.8MDefining the role of FUS phosphorylation in neurodegenerationR01NS093362 · NINDS · EMORY UNIVERSITY · PI KUKAR, THOMAS L · 2015 to 2019
$1.7MNIA NIH HHS P50 AG025688NIA NIH HHS R21 AG056781NIA NIH HHS RF1 AG051514NIA NIH HHS RF1 AG057247NIEHS NIH HHS R01 ES026892NIH HHS P51 OD011132NINDS NIH HHS K08 NS099474NINDS NIH HHS K08 NS109344NINDS NIH HHS L30 NS108208NINDS NIH HHS P30 NS055077NINDS NIH HHS P50 NS098685NINDS NIH HHS R01 NS092122NINDS NIH HHS R01 NS093362NINDS NIH HHS R01 NS100090NINDS NIH HHS R01 NS105971NINDS NIH HHS R01 NS114130NINDS NIH HHS T32 NS007480
Abstract
Alpha-synuclein (αSyn
Indexed as
Protein AggregatesProteomealpha-SynucleinAnimalsBrainCell LineDown-RegulationGenome-Wide Association StudyHumansInflammationLysosomesMiceMice, Inbred C57BLMicrogliaParkinson DiseaseProgranulinsalpha-SynucleinGrn protein, mouseProgranulinsProtein AggregatesProteomeRecombinant ProteinsmicroglianeuroinflammationParkinson's diseaseproteomicssynuclein
Identifiers
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LicenceCC BY
Read underepoch 390
Registered trials
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.