ArticleFrontiers in neuroscience2020
Brain Structural and Functional Alterations Specific to Low Sleep Efficiency in Major Depressive Disorder.
Article in Frontiers in neuroscience, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers.
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27 citing papers in PubMed, 55 citations in OpenAlex.
- Association of Left Angular Gyrus-Right Middle Frontal Gyrus Functional Connectivity With Insomnia Severity in Major Depressive Disorder: Evidence From the DIRECT Consortium.CNS neuroscience & therapeutics · 2026Article
- Microbial enterotype is linked to episodic and working memories via brain function in the parietal and occipital cortices.BMC biology · 2026Article
- Altered gray matter volume in major depressive disorder patients with psychomotor retardation.Neuroreport · 2026Article
- Effects of sleep quality on the default mode network and on anxiety-depression symptoms in premenstrual syndrome.BMC psychiatry · 2025Article
- Multi-omics analyses of the gut microbiome, fecal metabolome, and multimodal brain MRI reveal the role ofPsychological medicine · 2025Article
- Multilevel brain functional connectivity and task-based representations explaining heterogeneity in major depressive disorder.Translational psychiatry · 2025Article
- Unveiling the invisible: How cutting-edge neuroimaging transforms adolescent depression diagnosis.World journal of psychiatry · 2025Article
- Multi-omics analyses identify gut microbiota-fecal metabolites-brain-cognition pathways in the Alzheimer's disease continuum.Alzheimer's research & therapy · 2025Article
- Effects of vision impairment on cognitive function: the bidirectional chain mediating role of sleep quality and psychological disorders.Frontiers in public health · 2025Article
- Gray matter volume microstructural alterations in chronic post-burn pruritus: a voxel-based morphometry analysis using 3D T1-weighted imaging.Frontiers in neuroscience · 2025Article
- Insomnia and Mental Health Outcomes After Catastrophic Disasters: A Cross-Sectional Study Examining the Long-Term Effects of the Beirut Port Explosion.Neuropsychiatric disease and treatment · 2025Article
- Microstructural Changes in the Cerebral White Matter After 12 Months of CPAP Treatment for Moderate to Severe Obstructive Sleep Apnoea: A TBSS Study.Nature and science of sleep · 2024Article
- Genetic mechanisms underlying local spontaneous brain activity in episodic migraine.Frontiers in neuroscience · 2024Article
- Identifying major depressive disorder with associated sleep disturbances through fMRI regional homogeneity at rest.BMC psychiatry · 2023Article
- Sex-dependent gut microbiota-brain-cognition associations: a multimodal MRI study.BMC neurology · 2023Article
- Differences in Gray Matter Volume in Cerebral Small Vessel Disease Patients with and without Sleep Disturbance.Brain sciences · 2023Article
- The role of brain white matter in depression resilience and response to sleep interventions.Brain communications · 2023Article
- Functional Connectivity of White Matter and Its Association with Sleep Quality.Nature and science of sleep · 2023Article
- Functional connectivity and structural changes of thalamic subregions in episodic migraine.The journal of headache and pain · 2022Article
- Brain structure and perfusion in relation to serum renal function indexes in healthy young adults.Brain imaging and behavior · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundSleep disturbance is common in patients with major depressive disorder (MDD), but the exploration of its neural underpinnings is limited by subjective sleep measurement and single-modality neuroimaging analyses.
methodsNinety six patients with MDD underwent polysomnography examinations and multi-modal magnetic resonance imaging (MRI) scans. According to sleep efficiency, patients were subdivided into well-matched normal sleep efficiency (NSE,
resultsThere was no significant difference in gray matter volume (GMV) between the NSE and LSE groups. Compared with the NSE group, the LSE group showed increased axial diffusivity in the left superior and posterior corona radiata, and left posterior limb and retrolenticular part of internal capsule. In addition, the LSE group exhibited decreased ReHo in the bilateral lingual gyri and right postcentral gyrus yet increased FCS in the left angular gyrus relative to the NSE group. Moreover, validation analyses revealed that these results remained after adjusting for the medication effect.
conclusionOur data indicate that preserved gray matter morphology, impaired white matter integrity, and decreased local synchronization degree yet increased FCS are specific to low SE in MDD patients. These findings of disassociation between structural and functional alterations might provide insights into the neural mechanisms of sleep disturbance in depression.
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