ArticleScientific reports2020
Maturational delay and asymmetric information flow of brain connectivity in SHR model of ADHD revealed by topological analysis of metabolic networks.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 27 citations in OpenAlex.
- Trial
- Brain-Behavior Relationships in Children With ADHD: Resting-state EEG Networks Underlying Executive Function and Neurological Soft Signs.Brain and behavior · 2026Article
- Both k-core percolation and directed graph analysis revealed succession and transition of voxels' spatiotemporal progress on dynamic correlation resting-state fMRI.Frontiers in human neuroscience · 2025Article
- Age-related changes in the architecture and biochemical markers levels in motor-related cortical areas of SHR rats-an ADHD animal model.Frontiers in molecular neuroscience · 2024Article
- Resting-State Functional MRI and PET Imaging as Noninvasive Tools to Study (Ab)Normal Neurodevelopment in Humans and Rodents.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Review
- Article
- Is Histamine and Not Acetylcholine the Missing Link between ADHD and Allergies? Speer Allergic Tension Fatigue Syndrome Re-Visited.Journal of clinical medicine · 2023Article
- Alterations in Social Brain Network Topology at Rest in Children With Autism Spectrum Disorder.Psychiatry investigation · 2022Article
- Article
- Front and center: Maturational dysregulation of frontal lobe functional neuroanatomic connections in attention deficit hyperactivity disorder.Frontiers in neuroanatomy · 2022Article
- Retained Primitive Reflexes and Potential for Intervention in Autistic Spectrum Disorders.Frontiers in neurology · 2022Review
- Topological Analysis on Multi-scenario Graphs: Applications Toward Discerning Variability in SARS-CoV-2 and Topic Similarity in Research.Transactions of the Indian National Academy of Engineering : an international journal of engineering and technology · 2022Article
- Impaired Local and Long-Range Brain Connectivity and Visual Response in a Genetic Rat Model of Hyperactivity Revealed by Functional Ultrasound.Frontiers in neuroscience · 2022Article
- Caffeine Improves GABA Transport in the Striatum of Spontaneously Hypertensive Rats (SHR).Neurotoxicity research · 2021Article
- Improvement of Pursuit Eye Movement Alterations after Short Visuo-Attentional Training in ADHD.Brain sciences · 2020Article
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Authors and funding
11 authors at 3 institutions in 2 countries.
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No grant is acknowledged in the PubMed record.
Abstract
Attention-deficit hyperactivity disorder (ADHD) is a complex brain development disorder characterized by hyperactivity/impulsivity and inattention. A major hypothesis of ADHD is a lag of maturation, which is supported mainly by anatomical studies evaluating cortical thickness. Here, we analyzed changes of topological characteristics of whole-brain metabolic connectivity in twelve SHR rats selected as ADHD-model rats by confirming behavior abnormalities using the marble burying test, open field test, and delay discounting task and 12 Wistar Kyoto rats as the control group, across development from 4 weeks old (childhood) and 6 weeks old (entry of puberty). A topological approach based on graph filtrations revealed a lag in the strengthening of limbic-cortical/subcortical connections in ADHD-model rats. This in turn related to impaired modularization of memory and reward-motivation associated regions. Using mathematical network analysis techniques such as single linkage hierarchical clustering and volume entropy, we observed left-lateralized connectivity in the ADHD-model rats at 6 weeks old. Our findings supported the maturational delay of metabolic connectivity in the SHR model of ADHD, and also suggested the possibility of impaired and compensative reconfiguration of information flow over the brain network.
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