ArticleNature communications2020
X-ray structure of LeuT in an inward-facing occluded conformation reveals mechanism of substrate release.
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Article in Nature communications, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
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35citing papers in PubMed
3.1field-weighted citation impact, top 7% of its field
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35 citing papers in PubMed, 55 citations in OpenAlex.
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- Structural basis for selective inhibition of human GABA transporter GAT3.Nature communications · 2026Article
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- Structural insights into the substrate uptake and inhibition of the human creatine transporter (hCRT).Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- The RNF/NQR redox pumps: a versatile system for energy transduction in bacteria and archaea.Applied microbiology and biotechnology · 2025Review
- Control of Conformational Transitions by the Conserved GXInternational journal of molecular sciences · 2025Article
- Exploring the Structural Dynamics of LeuT Using EPR Spectroscopy: A Focus on Transmembrane Helix 10.Journal of neurochemistry · 2025Article
- Monitoring conformational changes in the human neurotransmitter transporter homologue LeuT withJournal of neurochemistry · 2025Article
- The Role of Protonation in the PfMATE Transporter Protein Structural Transitions.Methods in molecular biology (Clifton, N.J.) · 2025Article
- Alternating access of a bacterial homolog of neurotransmitter: sodium symporters determined from AlphaFold2 ensembles and DEER spectroscopy.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
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- Single-Molecule Imaging of Integral Membrane Protein Dynamics and Function.Annual review of biophysics · 2024Review
- Structure and function of the SIT1 proline transporter in complex with the COVID-19 receptor ACE2.Nature communications · 2024Article
- Haploinsufficiency underlies the neurodevelopmental consequences of SLC6A1 variants.American journal of human genetics · 2024Article
- Conformational free-energy landscapes of a NaProceedings of the National Academy of Sciences of the United States of America · 2024Article
- Oligomerization of Monoamine Transporters.Sub-cellular biochemistry · 2024Review
- Cryo-EM structure of GABA transporter 1 reveals substrate recognition and transport mechanism.Nature structural & molecular biology · 2023Article
- Molecular basis for substrate recognition and transport of human GABA transporter GAT1.Nature structural & molecular biology · 2023Article
- Structure-based discovery of conformationally selective inhibitors of the serotonin transporter.Cell · 2023Article
- Taurine and Creatine Transporters as Potential Drug Targets in Cancer Therapy.International journal of molecular sciences · 2023Review
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Authors and funding
15 authors at 5 institutions in 2 countries.
Kamil Gotfryd *Molecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-5, DK-2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0002-0299-0779
Thomas Boesen *DANDRITE - Nordic EMBL Partnership for Molecular Medicine, Department of Molecular Biology and Genetics, Aarhus University, DK-8000, Aarhus C, Denmark.ORCID http://orcid.org/0000-0002-5633-6844
Jonas S MortensenMolecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-5, DK-2200, Copenhagen N, Denmark.
George KhelashviliDepartment of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, New York, NY, NY10065, USA.ORCID http://orcid.org/0000-0001-7235-8579
Matthias QuickDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeon and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA.
Daniel S TerryDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.
Julie W MisselMembrane Protein Structural Biology Group, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0002-9727-1274
Michael V LeVineDepartment of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, New York, NY, NY10065, USA.
Pontus GourdonMembrane Protein Structural Biology Group, Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-9, DK-2200, Copenhagen N, Denmark.ORCID http://orcid.org/0000-0002-8631-3539
Scott C BlanchardDepartment of Structural Biology, St. Jude Children's Research Hospital, Memphis, TN, 38105, USA.ORCID http://orcid.org/0000-0003-2717-9365
Jonathan A JavitchDepartment of Psychiatry, Columbia University Vagelos College of Physicians & Surgeon and Division of Molecular Therapeutics, New York State Psychiatric Institute, New York, NY, 10032, USA.
Harel WeinsteinDepartment of Physiology and Biophysics, Weill Cornell Medical College, Cornell University, New York, NY, NY10065, USA.ORCID http://orcid.org/0000-0003-3473-9818
Claus J LolandMolecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-5, DK-2200, Copenhagen N, Denmark. cllo@sund.ku.dk.ORCID http://orcid.org/0000-0002-1773-1446
Poul NissenDANDRITE - Nordic EMBL Partnership for Molecular Medicine, Department of Molecular Biology and Genetics, Aarhus University, DK-8000, Aarhus C, Denmark. pn@mbg.au.dk.ORCID http://orcid.org/0000-0003-0948-6628
Ulrik GetherMolecular Neuropharmacology and Genetics Laboratory, Department of Neuroscience, Faculty of Health and Medical Sciences, University of Copenhagen, Maersk Tower 7-5, DK-2200, Copenhagen N, Denmark. gether@sund.ku.dk.ORCID http://orcid.org/0000-0002-0020-3807
University of Copenhagen · DKCornell University · USAarhus University · DKNew York Psychoanalytic Society and Institute · USSt. Jude Children's Research Hospital · US
Funding
STRUCTURE/FUNCTION OF THE HUMAN DOPAMINE TRANSPORTERP01DA012408 · NIDA · WEILL MEDICAL COLL OF CORNELL UNIV · PI WEINSTEIN, HAREL · 1999 to 2015
$14.2MProbing mechanisms of amphetamine action at plasma membrane and vesicular transporters in vitro and in vivoR01DA041510 · NIDA · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI JAVITCH, JONATHAN A · 2017 to 2021
$2.7MNIDA NIH HHS P01 DA012408NIDA NIH HHS R01 DA041510
Abstract
Neurotransmitter:sodium symporters (NSS) are conserved from bacteria to man and serve as targets for drugs, including antidepressants and psychostimulants. Here we report the X-ray structure of the prokaryotic NSS member, LeuT, in a Na
Indexed as
Amino Acid SubstitutionAquifexBacteriaBacterial ProteinsBinding SitesCrystallography, X-RayLeucineMolecular Dynamics SimulationMutagenesis, Site-DirectedPlasma Membrane Neurotransmitter Transport ProteinsProtein ConformationBacterial ProteinsLeucinePlasma Membrane Neurotransmitter Transport Proteins
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