ArticleScientific reports2020
Association between Serum Calcium and Risk of Cardiometabolic Disease among Community-dwelling Adults in Taiwan.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 23 citations in OpenAlex.
- Defining the potential role of the mineralocorticoid receptor in musculoskeletal health and bone crosstalk with other tissues.The Journal of endocrinology · 2026Review
- Serum calcium, even within normal range, is associated with blood pressure with a potential influence of calcium intake.Journal of the Endocrine Society · 2026Article
- Debating the link between atrial fibrillation and psychiatric diseases through CaWorld journal of psychiatry · 2025Review
- Association of serum magnesium and calcium with metabolic syndrome: a cross-sectional study from the Qatar-biobank.Nutrition & metabolism · 2025Article
- Plasma Levels of Magnesium, Calcium, Calcium to Magnesium Ratio, and Associations with Metabolic Syndrome and Cardiometabolic Risk Factors.Biological trace element research · 2024Article
- Association of serum calcium and metabolically healthy obese in US adults: a cross-sectional study.Annals of medicine · 2024Article
- Calcium, Phosphate, and Vitamin D in Children and Adolescents with Chronic Diseases: A Cross-Sectional Study.Nutrients · 2024Article
- Cross-sectional association between blood cholesterol and calcium levels in genetically diverse strains of mice.FEBS open bio · 2024Article
- CaWorld journal of diabetes · 2023Article
- Association of urine phthalate metabolites, bisphenol A levels and serum electrolytes with 24-h blood pressure profile in adolescents.BMC nephrology · 2022Article
- Corrected Serum Ionized Calcium as a Risk Factor Related to Adult Dyslipidemia.Frontiers in cardiovascular medicine · 2022Article
- Serum Calcium Level as a Useful Surrogate for Risk of Elevated Intraocular Pressure.Journal of clinical medicine · 2021Article
- Association Between Serum Calcium and the Prevalence of Hypertension Among US Adults.Frontiers in cardiovascular medicine · 2021Article
- Temporal Relationship Between Changes in Serum Calcium and Hypercholesteremia and Its Impact on Future Brachial-Ankle Pulse Wave Velocity Levels.Frontiers in nutrition · 2021Article
- The Role of Serum Calcium Levels in Pediatric Dyslipidemia: Are There Any?Frontiers in pediatrics · 2021Article
- Increased serum calcium levels are associated with carotid atherosclerotic plaque in normocalcaemic individuals with type 2 diabetes.Therapeutic advances in endocrinology and metabolism · 2021Article
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Serum calcium, although only comprising 1% of total body calcium, is involved in intracellular signal pathways, vascular dilatation/constriction, and muscle contraction, which are crucial for insulin secretion, cholesterol catabolism, and blood pressure regulation. As far as we know, research on the relationship between serum calcium level and metabolic syndrome (MetS), diabetes, and hypertension in one longitudinal study is rare. Owing to the crucial role of serum calcium in human cardiometabolic physiology and lack of related study so far, this study aims to describe the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. During the period 2010-2016, there are two parts to our study: cross-sectional analysis and longitudinal analysis. Logistic regression was applied for cross-sectional analysis of the association between serum calcium level or albumin-corrected calcium (ACCA) and the prevalence of MetS, diabetes, or hypertension. Receiver operating characteristic (ROC) curve analysis was used for calculating of optimal cut-off value of serum calcium and ACCA. Cox proportional regression for development of MetS, diabetes, and hypertension according to different cut-off values of serum calcium level and ACCA were conducted. At baseline, there were 27,364 participants in our study. Serum calcium level had positive association with diabetes in the total population, male, and female. ACCA level had positive association with diabetes in the total population, male, and female. In unadjusted and multivariate Cox proportional hazard models, serum calcium level was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident MetS in the total population and male. ACCA was associated with increased risk of incident diabetes in the total population and male participants. This study describes the relationship between serum calcium level and the incidence of MetS, diabetes, and hypertension. Higher serum calcium level is associated with increased risk of MetS, diabetes, and hypertension.
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