Evidence map›Paper›PMID 32081619›Full record

ArticleAnalytical biochemistry2020

A sensitive LC-MS assay using derivatization with boron trifluoride to quantify curcuminoids in biological samples.

Alexander J Yoon, Haiqiang Wu, Roy D Pan, Bruce Teter, Jack Cipolla, Edwin Chang, Luis Z Avila, Saroj K Basak, Eri S Srivatsan, Marilene B Wang and 4 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Analytical biochemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.7field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 9 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 2 countries.

Alexander J YoonPasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA. Electronic address: yoon2887@g.ucla.edu.
Haiqiang WuPasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA; School of Pharmaceutical Sciences, Health Science Center, Shenzhen University, Shenzhen 518060, China.
Roy D PanDepartment of Chemistry & Biochemistry, University of California Los Angeles, Los Angeles, CA 90095, USA; Department of Molecular & Medical Pharmacology, University of California Los Angeles, Los Angeles, CA, 90095, USA.
Bruce TeterDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Jack CipollaPasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
Edwin ChangDepartment of Radiology, Stanford University, Stanford, CA 94305, USA.
Luis Z AvilaAveta Biomics, Bedford, MA, 01730, USA.
Saroj K BasakDepartment of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA; Department of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA.
Eri S SrivatsanDepartment of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Department of Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA; Department of Surgery, Veterans Administration Greater Los Angeles Health System, Los Angeles, CA 90073, USA; Department of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA.
Marilene B WangDepartment of Head & Neck Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA 90073, USA; Department of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.
Greg M ColeDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Sally A FrautschyDepartment of Neurology, David Geffen School of Medicine, University of California Los Angeles, Los Angeles, CA 90095, USA.
Phillip D HamptonDepartment of Chemistry, California State University Channel Islands, Camarillo, CA 93012, USA.
Kym F FaullPasarow Mass Spectrometry Laboratory, Jane and Terry Semel Institute for Neuroscience and Human Behavior and Department of Psychiatry & Biobehavioral Sciences, David Geffen School of Medicine at UCLA, Los Angeles, CA 90095, USA.
University of California, Los Angeles · USCalifornia State University, Channel Islands · USVA Greater Los Angeles Healthcare System · USShenzhen University Health Science Center · CNStanford University · US

Funding

Preclinical Pharmacogenomics and Synaptic Biomarkers for Alzheimer's DiseaseR01AT006816 · NCCIH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, GREGORY M, FRAUTSCHY, SALLY ANN · 2011 to 2015
$1.9M
Diet and Exercise (DE) Program for Alzheimer PreventionRC1AG035878 · NIA · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI COLE, GREGORY M, FRAUTSCHY, SALLY ANN · 2009 to 2010
$1.0M
BLRD VA I01 BX000542BLRD VA I01 BX001257BLRD VA I01 BX003485NCCIH NIH HHS R01 AT006816NIA NIH HHS RC1 AG035878RRD VA I01 RX000669
6 · The paper itself

Abstract

A procedure is described to measure curcumin (C), demethoxycurcumin (DMC), bisdemethoxycurcumin (BDMC), tetrahydrocurcumim (TC) and their glucuronidated metabolites (CG, DMCG, and BDMCG) in plasma, brain, liver and tumor samples. The procedure involves converting the analytes to their boron difluoride derivatives and analyzing them by combined liquid chromatography coupled to an ion trap mass spectrometer operating in the negative ion MS

Indexed as

AnimalsBoranesChromatography, LiquidDiarylheptanoidsHealthy VolunteersHumansMass SpectrometryMiceMolecular StructureBoranesboron trifluorideDiarylheptanoidsBoron trifluoride (BF(3))CurcuminCurcuminoidsLiquid chromatography coupled mass spectrometry (LCMS)Pharmacokinetics

Identifiers

PMID32081619
PMCPMC10631463
OpenAlexW3007898509

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.