ArticleInternational journal of medical microbiology : IJMM2020
Complete genome sequence and genome-scale metabolic modelling of Acinetobacter baumannii type strain ATCC 19606.
Article in International journal of medical microbiology : IJMM, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 29 citations in OpenAlex.
- Peptoid-based antimicrobial strategies against polymyxin-resistant Gram-negative bacteria.Journal of applied microbiology · 2026Article
- Harnessing epitope reciprocity and multimeric epitope density for a novel multiepitope vaccine design against Acinetobacter baumannii.Scientific reports · 2026Article
- Inter- and intra-bacterial strain diversity remains the "elephant in the (living) room".npj antimicrobials and resistance · 2025Review
- Mechanisms of action and resistance prevention of synergistic thymol and carvacrol combinations with antibiotics in Staphylococcus aureus and Acinetobacter baumannii.Natural products and bioprospecting · 2025Article
- Antimicrobial activity of peptoids against Metallo-β-lactamase-producing Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, and other WHO priority pathogens, including Candida auris.Journal of applied microbiology · 2025Article
- Exploring the Multifaceted GenusJournal of microbiology and biotechnology · 2025Review
- Antimicrobial resistance and virulence factors analysis of a multidrug-resistant Acinetobacter baumannii isolated from chickens using whole-genome sequencing.BMC microbiology · 2024Article
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- Farnesol repurposing for prevention and treatment ofBiofilm · 2024Article
- Antibacterial Activity and Proposed Mode of Action of Extracts from Selected Zimbabwean Medicinal Plants againstAdvances in pharmacological and pharmaceutical sciences · 2024Article
- Electrostatic Loading and Photoredox-Accelerated Release of Antibiotics from Oligoviologen-Crosslinked Hydrogels Using Red Light.Materials today. Chemistry · 2024Article
- Development of a high-throughput minimum inhibitory concentration (HT-MIC) testing workflow.Frontiers in microbiology · 2023Article
- Transcriptome Analysis ofInternational journal of environmental research and public health · 2022Article
- Computer-Based Identification of Potential Druggable Targets in Multidrug-ResistantMicroorganisms · 2022Article
- Genome diversity of domesticatedMicrobial genomics · 2022Article
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- Analysis of Complete Genome Sequence ofMicroorganisms · 2020Article
- Genome-Scale Metabolic Modeling Reveals Metabolic Alterations of Multidrug-ResistantMicroorganisms · 2020Article
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
Multidrug-resistant (MDR) Acinetobacter baumannii is a critical threat to global health. The type strain ATCC 19606 has been widely used in studying the virulence, pathogenesis and mechanisms of antimicrobial resistance in A. baumannii. However, the lack of a complete genome sequence is a hindrance towards detailed bioinformatic studies. Here we report the generation of a complete genome for ATCC 19606 using PacBio sequencing. ATCC 19606 genome consists of a 3,980,848-bp chromosome and a 9,450-bp plasmid pMAC, and harbours a chromosomal dihydropteroate synthase gene sul2 conferring resistance to sulphonamides and a plasmid-borne ohr gene conferring resistance to peroxides. The genome also contains 69 virulence genes involved in surface adherence, biofilm formation, extracellular phospholipase, iron uptake, immune evasion and quorum sensing. Insertion sequences ISCR2 and ISAba11 are embedded in a 36.1-Kb genomic island, suggesting an IS-mediated large-scale DNA recombination. Furthermore, a genome-scale metabolic model (GSMM) iATCC19606v2 was constructed using the complete genome annotation. The model iATCC19606v2 incorporated a periplasmic compartment, 1,422 metabolites, 2,114 reactions and 1,009 genes, and a set of protein crowding constraints taking into account enzyme abundance limitation. The prediction of bacterial growth on 190 carbon and 95 nitrogen sources achieved a high accuracy of 85.6% compared to Biolog experiment results. Based upon two transposon mutant libraries of AB5075 and ATCC 17978, the predictions of essential genes reached the accuracy of 87.6% and 82.1%, respectively. Together, the complete genome sequence and high-quality GSMM iATCC19606v2 provide valuable tools for antimicrobial systems pharmacological investigations on A. baumannii.
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