Evidence map›Paper›PMID 32081448›Full record

ArticleBioorganic & medicinal chemistry letters2020

Conjugation of peptides to short-acyl-chain ceramides for delivery across mucosal cell barriers.

Richard I Duclos, Kiara D Blue, Michael J Rufo, Xiaoling Chen, Jason J Guo, Xiaoyu Ma, Wayne I Lencer, Daniel J F Chinnapen

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Bioorganic & medicinal chemistry letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact, top 99% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Review
  3. Sorting of complex sphingolipids within the cellular endomembrane systems.Frontiers in cell and developmental biology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Richard I DuclosDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States. Electronic address: Richard.Duclos@childrens.harvard.edu.
Kiara D BlueDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States. Electronic address: bluekiara@gmail.com.
Michael J RufoDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States. Electronic address: michael.j.rufo@gmail.com.
Xiaoling ChenDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States. Electronic address: Xiaoling.Chen@umassmed.edu.
Jason J GuoBarnett Institute for Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States. Electronic address: J.Guo@northeastern.edu.
Xiaoyu MaBarnett Institute for Chemical and Biological Analysis, Department of Chemistry and Chemical Biology, Northeastern University, Boston, MA 02115, United States. Electronic address: Ma.Xiaoy@husky.neu.edu.
Wayne I LencerDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States; Harvard Digestive Diseases Center, Boston, MA 02115, United States. Electronic address: Wayne.Lencer@childrens.harvard.edu.
Daniel J F ChinnapenDivision of Gastroenterology and Nutrition, Department of Pediatrics, Boston Children's Hospital, Boston, MA 02115, United States; Department of Pediatrics, Harvard Medical School, Boston, MA 02115, United States. Electronic address: Dan.Chinnapen@childrens.harvard.edu.
Boston Children's Hospital · USNortheastern University · USHarvard University · US

Funding

STRUCTURE-FUNCTION RELATIONSHIPS IN THE ALIMENTARY TRACTP30DK034854 · NIDDK · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI JONATHAN C KAGAN · 1986 to 2026
$32.4M
COngenital Diarrhea and Enteropathy (PediCODE) Consortium and BioRepositoryRC2DK118640 · NIDDK · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI James Richard Goldenring, Izumi Kaji · 2019 to 2026
$14.8M
Intestinal Disease-enterocyte toxin interactionR37DK048106 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LENCER, WAYNE I · 2011 to 2020
$7.0M
Harnessing the biology of glycosphingolipid trafficking for biologic drug deliveryR01DK104868 · NIDDK · BOSTON CHILDREN'S HOSPITAL · PI LENCER, WAYNE I · 2016 to 2019
$1.8M
NIDDK NIH HHS P30 DK034854NIDDK NIH HHS R01 DK104868NIDDK NIH HHS R37 DK048106NIDDK NIH HHS RC2 DK118640
6 · The paper itself

Abstract

Robust transport of therapeutic peptides and other medicinal molecules across tight epithelial barriers would overcome the major obstacle to oral delivery. We have already demonstrated that peptides conjugated to gangliosides (GM1 and GM3) having non-native short N-acyl groups hijack the endogenous process of intracellular lipid sorting resulting in transcytosis and delivery across epithelial barriers in vitro and in vivo. Here, we report synthetic methodologies to covalently conjugate peptides directly to short-acyl-chain C

Indexed as

Biological Transport, ActiveCells, CulturedCeramidesDose-Response Relationship, DrugEpithelial CellsHumansIntestinal MucosaMolecular StructurePeptidesStructure-Activity RelationshipCeramidesPeptidesC(6)-ceramideOral peptide deliveryShort-acyl-chainTranscytosis

Identifiers

PMID32081448
PMCPMC7174066
OpenAlexW3004621166

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.