Evidence map›Paper›PMID 32081407›Full record

ReviewSeminars in perinatology2020

Pharmacogenomics in pregnancy.

Hannah K Betcher, Alfred L George

Open access · greenAbstract readReview
In one paragraph

Review in Seminars in perinatology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 25 citations in OpenAlex.

  1. Trial
  2. Obstetric pharmacogenomics.Journal of basic and clinical physiology and pharmacology · 2026
    Review
  3. Article
  4. Review
  5. Article
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  7. Review
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  9. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Hannah K BetcherDepartment of Psychiatry, Northwestern University Feinberg School of Medicine, 676N St. Clair St. Ste 1000, Chicago IL, USA; Mayo Clinic, Rochester, MN, USA. Electronic address: betcher.hannah@mayo.edu.
Alfred L GeorgeDepartment of Pharmacology and Center for Pharmacogenomics, Northwestern University Feinberg School of Medicine, Searle 8-510, 320 East Superior Street, Chicago, IL 60611, USA. Electronic address: al.george@northwestern.edu.
Mayo Clinic in Arizona · USNorthwestern University · US

Funding

Plasma SSRI Concentrations and CYP450 Activity Across ChildbearingU54HD085601 · NICHD · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GEORGE, ALFRED L. · 2015 to 2019
$3.9M
NICHD NIH HHS U54 HD085601
6 · The paper itself

Abstract

Pregnant women frequently take prescription and over the counter medications. The efficacy of medications is affected by the many physiological changes during pregnancy, and these events may be further impacted by genetic factors. Research on pharmacogenomic and pharmacokinetic influences on drug disposition during pregnancy has lagged behind other fields. Clinical investigators have demonstrated altered activity of several drug metabolizing enzymes during pregnancy. Emerging evidence also supports the influence of pharmacogenomic variability in drug response for many important classes of drugs commonly used in pregnancy. Prescribing medications during pregnancy requires an understanding of the substantial dynamic physiologic and metabolic changes that occur during gestation. Pharmacogenomics also contributes to the inter-individual variability in response to many medications, and more research is needed to understand how best to manage drug therapy in pregnant women.

Indexed as

PharmacogeneticsAnalgesics, OpioidAntidepressive AgentsAntiemeticsAntihypertensive AgentsCytochrome P-450 Enzyme SystemDrug Elimination RoutesFemaleHumansPharmaceutical PreparationsPharmacogenomic VariantsPharmacokineticsPregnancyAnalgesics, OpioidAntidepressive AgentsAntiemeticsAntihypertensive AgentsCytochrome P-450 Enzyme SystemPharmaceutical PreparationsDrug metabolismDrug therapyPharmacogeneticsPharmacogenomicsPregnancy

Identifiers

PMID32081407
PMCPMC7214196
OpenAlexW3002224781

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.