SynthesisVox sanguinis2020
Anti-platelet antibody immunoassays in childhood immune thrombocytopenia: a systematic review.
Synthesis in Vox sanguinis, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it, 17 citations in OpenAlex.
- Gut microbiome alterations in immune thrombocytopenia: a systematic review of current evidence.Frontiers in medicine · 2025Pooled it
- Anti-platelet antibodies in childhood immune thrombocytopenia: Prevalence and prognostic implications.Journal of thrombosis and haemostasis : JTH · 2020Trial
- Multisystem hemorrhage in a very preterm infant born to a mother with immune thrombocytopenia: a case report and literature review.Frontiers in pediatrics · 2026Article
- Evaluation of the hematological inflammatory parameters in the patients with immune thrombocytopenic purpura: A case-control study.Health science reports · 2024Article
- Proceedings of the immune thrombocytopenia summit: new concepts in mechanisms, diagnosis, and management.Research and practice in thrombosis and haemostasis · 2023Review
- Gut microbiota alterations in children and their relationship with primary immune thrombocytopenia.Frontiers in pediatrics · 2023Article
- Meropenem-induced thrombocytopenia: a paediatric case.BMJ case reports · 2021Article
- Potential Diagnostic Approaches for Prediction of Therapeutic Responses in Immune Thrombocytopenia.Journal of clinical medicine · 2021Review
- Biological stratification of clinical disease courses in childhood immune thrombocytopenia.Journal of thrombosis and haemostasis : JTH · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
backgroundIn adult immune thrombocytopenia (ITP), an acquired autoimmune bleeding disorder, anti-platelet autoantibody testing may be useful as a rule-in test. Childhood ITP has different disease characteristics, and the diagnostic and prognostic value of anti-platelet antibody testing remains uncertain.
objectiveTo systematically review the diagnostic accuracy of anti-platelet autoantibody testing in childhood ITP.
methodsPubMed and EMBASE were searched for studies evaluating immunoassays in childhood ITP. Study quality was assessed (QUADAS2), and evidence was synthesized descriptively.
resultsIn total, 40 studies (1606 patients) were identified. Nine studies reported sufficient data to determine diagnostic accuracy measures. Anti-platelet IgG antibody testing showed a moderate sensitivity (0·36-0·80 platelet-associated IgG [direct test]; 0·19-0·39 circulating IgG [indirect test]). In studies that reported control data, including patients with non-immune thrombocytopenia, specificity was very good (0·80-1·00). Glycoprotein-specific immunoassays showed comparable sensitivity (three studies) and predominantly identified IgG anti-GP IIb/IIIa antibodies, with few IgG anti-GP Ib/IX antibodies. Anti-platelet IgM antibodies were identified in a substantial proportion of children (sensitivity 0·62-0·64 for direct and indirect tests).
conclusionThe diagnostic evaluation of IgG and IgM anti-platelet antibodies may be useful as a rule-in test for ITP. In children with insufficient platelets for a direct test, indirect tests may be performed instead. A negative test does not rule out the diagnosis of ITP. Future studies should evaluate the value of anti-platelet antibody tests in thrombocytopenic children with suspected ITP.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.