Evidence map›Paper›PMID 32080784›Full record

ArticleNeurochemical research2020

Synergic Effects of Berberine and Curcumin on Improving Cognitive Function in an Alzheimer's Disease Mouse Model.

Lin Lin, Cheng Li, Deyi Zhang, Mingxiang Yuan, Chun-Hai Chen, Maoquan Li

Abstract read
PubMed Publisher
In one paragraph

Article in Neurochemical research, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
34citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

34 citing papers in PubMed, 2 syntheses or guidelines pooled it, 65 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
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  4. Article
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  12. Observational
  13. Review
  14. Effectiveness of Novel Drug Delivery System using Curcumin in Alzheimer's Disease.Central nervous system agents in medicinal chemistry · 2024
    Review
  15. Article
  16. Article
  17. Article
  18. Review
  19. Article
  20. Neuroprotective Effect of Root Extracts ofJournal of pharmacopuncture · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Lin LinCollaborative Innovation Center of Sichuan for Elderly Care and Health, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Cheng LiDepartment of Public Health, Chengdu Medical College, Chengdu, 610500, Sichuan, China.
Deyi ZhangDepartment of Anesthesiology, Mianyang People's Hospital, Mianyang, 621000, Sichuan, China.
Mingxiang YuanDepartment of Gynaecology and Obstetrics, Mianyang People's Hospital, Mianyang, 621000, Sichuan, China.
Chun-Hai ChenDepartment of Occupational Health, Amy Medical University, Chongqing, 400038, China. chunhai2000@163.com.ORCID http://orcid.org/0000-0002-7549-213X
Maoquan LiAffiliated Traditional Chinese Medicine Hospital of Chengdu Medical College, Chengdu, 610300, Sichuan, China. 917604412@qq.com.
Chengdu Medical College · CNSichuan Mianyang 404 Hospital · CNChongqing Medical University · CN

Funding

State Administration of Traditional Chinese Medicine of the People's Republic of China (CN) 2018KF016the soft science of Sichuan Provincial Science and Technology Department 18Z081
6 · The paper itself

Abstract

Alzheimer's disease (AD) is one of the most common neurodegenerative diseases, and no effective therapies have been found to prevent or cure AD to date. Berberine and curcumin are extracts from traditional Chinese herbs that have a long history of clinical benefits for AD. Here, using a transgenic AD mouse model, we found that the combined berberine and curcumin treatment had a much better effect on improving the cognitive function of mice than the single-drug treatment, suggesting synergic effects of the combined berberine and curcumin treatment. In addition, we found that the combined berberine and curcumin treatment had significant synergic effects on reducing soluble amyloid-β-peptide

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesAmyloid Precursor Protein SecretasesAnimalsAnti-Inflammatory Agents, Non-SteroidalAspartic Acid EndopeptidasesBerberineBrainCognitionCurcuminDrug SynergismFemaleMaleMiceMice, TransgenicOxidative StressAmyloid beta-Peptidesamyloid beta-protein (1-42)Amyloid Precursor Protein SecretasesAnti-Inflammatory Agents, Non-SteroidalAspartic Acid EndopeptidasesBace1 protein, mouseBerberineCurcuminPeptide FragmentsAlzheimer’s diseaseBerberineCognitive functionCurcuminInflammatory responsesOxidative stress

Identifiers

PMID32080784
OpenAlexW3007744184

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.