Evidence map›Paper›PMID 32080690›Full record

ArticleDalton transactions (Cambridge, England : 2003)2020

Enhancing

Louise R Tear, Mahon L Maguire, Manuel Tropiano, Kezi Yao, Nicola J Farrer, Stephen Faulkner, Jurgen E Schneider

Abstract read
In one paragraph

Article in Dalton transactions (Cambridge, England : 2003), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. ATP-responsive Mn(II)-basedChemical communications (Cambridge, England) · 2023
    Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Louise R TearChemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK. stephen.faulkner@chem.ox.ac.uk and British Heart Foundation Experimental MR Unit (BMRU), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK.
Mahon L MaguireBritish Heart Foundation Experimental MR Unit (BMRU), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK and Centre for Preclinical Imaging, University of Liverpool, Nuffield Wing, Sherrington Building, Crown Street, Liverpool, L69 3BX, UK.
Manuel TropianoChemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK. stephen.faulkner@chem.ox.ac.uk.
Kezi YaoChemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK. stephen.faulkner@chem.ox.ac.uk.
Nicola J FarrerChemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK. stephen.faulkner@chem.ox.ac.uk.ORCID http://orcid.org/0000-0002-7440-1291
Stephen FaulknerChemistry Research Laboratory, University of Oxford, Mansfield Road, OX1 3TA, UK. stephen.faulkner@chem.ox.ac.uk.ORCID http://orcid.org/0000-0003-1878-5857
Jurgen E SchneiderBritish Heart Foundation Experimental MR Unit (BMRU), University of Oxford, Roosevelt Drive, Oxford, OX3 7BN, UK and Leeds Institute of Cardiovascular and Metabolic Medicine, Biomedical Imaging Science Department, University of Leeds, Clarendon Way, Leeds, LS2 9JT, UK.ORCID http://orcid.org/0000-0003-0999-5684

Funding

British Heart Foundation FS/11/50/29038Wellcome Trust 201406Wellcome Trust 201406/Z/16/Z
6 · The paper itself

Abstract

The kinetically stable heptadentate gadolinium complex Gd.pDO3A (1.Gd) demonstrates significant 31P nuclear magnetic resonance (NMR) relaxation enhancement of biologically relevant phosphate species; adenosine triphosphate (ATP), phosphocreatine (PCr) and inorganic phosphate. Gd.pDO3A (1.Gd) binds these species in fast exchange, enabling the relaxation of the bulk phosphate species in solution. This gives rise to 31P relaxation enhancements up to 250-fold higher than those observed for 31P relaxation enhancements with the commercial MRI contrast agent Gd.DOTA (DOTAREM), 2. Gd.pDO3A-like complexes may have potential applications as 31P magnetic resonance contrast agents, since shortening the T1 relaxation time of phosphate species would reduce the time needed to acquire 31P-MR spectra.

Identifiers

PMID32080690
PMCPMC7610995

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.