ArticleNature chemical biology2020
Redox lipid reprogramming commands susceptibility of macrophages and microglia to ferroptotic death.
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Article in Nature chemical biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 424 papers, 1 of them a synthesis that pooled it.
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424citing papers in PubMed, 1 pooled it
24.5field-weighted citation impact, top 1% of its field
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Who cites it
424 citing papers in PubMed, 1 synthesis or guideline pooled it, 604 citations in OpenAlex.
- Bibliometric analysis of cognitive dysfunction after traumatic brain injury.Frontiers in neuroscience · 2025Pooled it
- Arginine metabolism, polyamine homeostasis and ferroptosis in cancer: Molecular links and therapeutic opportunities (Review).Molecular medicine reports · 2026Review
- Ferroptosis in cancer: molecular mechanisms, biological roles, and therapeutic significance.Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico · 2026Review
- Magnetically Guided Macrophage Immunobots Coordinate Iron-Metabolic Cascades and Immunogenic Ferroptosis for Tumor Immunotherapy.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Pharmacological targeting of ferroptosis in cancer: mechanisms, tumor immunity, and translational challenges.Pharmacological reports : PR · 2026Review
- The Emerging Role of Ferroptosis in Pediatric Cancer Biology and Therapy.International journal of molecular sciences · 2026Review
- Nano-formulations in therapeutic strategies targeting cancer ferroptosis.Journal of pharmaceutical analysis · 2026Review
- Ferroptosis: Newly Emerged Regulator for Human Disease.MedComm · 2026Review
- Mammalian Arachidonic Acid 15-Lipoxygenases: Fed-Batch Fermentation, Enzyme Purification and Functional Characterization.Metabolites · 2026Article
- Ferroptosis in T cells: mechanisms, biology and translational opportunities.Nature reviews. Immunology · 2026Review
- Menaquinone-4 protects CD8Science China. Life sciences · 2026Article
- Structural Improvement of the Allosteric ALOX15 Inhibitor Octyl (Molecules (Basel, Switzerland) · 2026Article
- The role of ferroptosis in the pathogenesis and treatment of breast cancer.Journal of translational medicine · 2026Review
- Intrinsic polyunsaturated fatty acid synthesis capacity dictates ferroptosis sensitivity under restricted arachidonic acid availability.Cell death discovery · 2026Article
- FerroScore: a statistical approach for quantifying tumor-related ferroptosis based on omics data.Briefings in bioinformatics · 2026Article
- Ferroptosis in colorectal cancer: Molecular mechanisms and regulatory crosstalk with therapeutic prospects (Review).Oncology reports · 2026Review
- Targeting the Fra2/LCN2 axis attenuates PMRedox biology · 2026Article
- Emerging roles of ferroptosis in modulating the immune landscape of glial tumours.Nature cell biology · 2026Review
- Integrative bulk and single-cell transcriptome analyses reveal RNA modification-related biomarkers of spinal cord injury.Neural regeneration research · 2026Article
- Immune network remodeling driven by ferroptosis: Bidirectional interaction mechanisms among multiple immune cells in the lung cancer immune microenvironment (Review).Oncology reports · 2026Review
364 more citing papers are in PubMed but not listed here.
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Authors and funding
26 authors at 5 institutions in 4 countries.
Alexandr A Kapralov *Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Qin Yang *Department of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Haider H Dar *Department of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Yulia Y TyurinaDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Tamil S AnthonymuthuDepartment of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0002-3460-5003
Rina KimThe Wistar Institute, Philadelphia, PA, USA.
Claudette M St CroixDepartment of Cell Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Karolina Mikulska-RuminskaDepartment of Computational and Systems Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Bing LiuDepartment of Computational and Systems Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Indira H ShrivastavaDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Vladimir A TyurinDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Hsiu-Chi TingDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Yijen L WuDepartment of Developmental Biology, Rangos Research Center of Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Yuan GaoDepartment of Critical Care Medicine, Safar Center for Resuscitation Research, Children's Neuroscience Institute, Children's Hospital of Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.
Galina V ShurinDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Margarita A ArtyukhovaDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-7946-0744
Liubov A PonomarevaDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Peter S TimashevLaboratory of Navigational Redox Lipidomics, Institute for Regenerative Medicine, IM Sechenov Moscow State Medical University, Moscow, Russia.
Rosario M DominguesMass Spectrometry Center, QOPNA, University of Aveiro, Aveiro, Portugal.
Detcho A StoyanovskyDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA.
Joel S GreenbergerDepartment of Radiation Oncology, University of Pittsburgh, Pittsburgh, PA, USA.
Rama K MallampalliDepartment of Internal Medicine, The Ohio State University, Columbus, OH, USA.
Ivet BaharDepartment of Computational and Systems Biology, Pittsburgh, University of Pittsburgh, Pittsburgh, PA, USA.ORCID http://orcid.org/0000-0001-9959-4176
Dmitry I GabrilovichThe Wistar Institute, Philadelphia, PA, USA. dgabrilovich@Wistar.org.ORCID http://orcid.org/0000-0001-9913-6407
Hülya BayırDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA. bayihx@ccm.upmc.edu.ORCID http://orcid.org/0000-0003-2361-4120
Valerian E KaganDepartment of Environmental and Occupational Health and Center for Free Radical and Antioxidant Health University of Pittsburgh, Pittsburgh, PA, USA. kagan@pitt.edu.ORCID http://orcid.org/0000-0002-7245-1885
University of Pittsburgh · USThe Wistar Institute · USSechenov University · RUThe Ohio State University · USUniversity of Aveiro · PT
Funding
Tumor Microenvironment and MetastasisP30CA010815 · NCI · WISTAR INSTITUTE · PI Maureen E. Murphy · 1985 to 2026
$75.9MTraining and EducationU19AI068021 · NIAID · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2005 to 2019
$44.4MRegulation of Cardiolin Byosynthesis in Epithelial InjuryP01HL114453 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MCVERRY, BRYAN J · 2014 to 2023
$21.3MTrainingP41GM103712 · NIGMS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI FAEDER, JAMES · 2012 to 2021
$16.3MNITRIC OXIDE AND METALLOTIONEIMP01HL070807 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI RYTER, STEFAN W · 2003 to 2007
$8.1MMapping Lipid Oxidation in Traumatic Brain Injury by Mass Spectrometric ImagingR01NS076511 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir, Valerian E Kagan · 2012 to 2026
$6.8MHEMATOPOIESIS TRAINING GRANTT32DK007780 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI TONG, WEI · 1999 to 2023
$6.7MF box-Induced Acute Lung Injury and ParkinR01HL096376 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI MALLAMPALLI, RAMA K · 2010 to 2025
$5.1MLipids and Myeloid Cell Function in CancerR01CA165065 · NCI · WISTAR INSTITUTE · PI KAGAN, VALERIAN E, MONTANER, LUIS J · 2012 to 2022
$3.8MOxidative Lipidomics in Pediatric Traumatic Brain InjuryR01NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BAYIR, HÜLYA · 2008 to 2018
$3.3MOxidative Lipidomics in Pediatric Traumatic Brain InjuryR37NS061817 · NINDS · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Hülya Bayir · 2021 to 2026
$2.2MNCI NIH HHS P30 CA010815NCI NIH HHS R01 CA165065NHLBI NIH HHS P01 HL070807NHLBI NIH HHS P01 HL114453NHLBI NIH HHS R01 HL096376NIAID NIH HHS U19 AI068021NIDDK NIH HHS T32 DK007780NIGMS NIH HHS P41 GM103712NINDS NIH HHS R01 NS061817NINDS NIH HHS R01 NS076511NINDS NIH HHS R37 NS061817
Abstract
Ferroptotic death is the penalty for losing control over three processes-iron metabolism, lipid peroxidation and thiol regulation-that are common in the pro-inflammatory environment where professional phagocytes fulfill their functions and yet survive. We hypothesized that redox reprogramming of 15-lipoxygenase (15-LOX) during the generation of pro-ferroptotic signal 15-hydroperoxy-eicosa-tetra-enoyl-phosphatidylethanolamine (15-HpETE-PE) modulates ferroptotic endurance. Here, we have discovered that inducible nitric oxide synthase (iNOS)/NO
Indexed as
AnimalsArachidonate 15-LipoxygenaseCell DeathFemaleFerroptosisIronLeukotrienesLipid PeroxidationLipid PeroxidesMacrophagesMaleMiceMice, Inbred C57BLMicrogliaNitric Oxide Synthase Type IIOxidation-Reduction15-hydroperoxy-5,8,11,13-eicosatetraenoic acidArachidonate 15-LipoxygenaseIronLeukotrienesLipid PeroxidesNitric Oxide Synthase Type IIReactive Oxygen Species
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.