Evidence map›Paper›PMID 32080393›Full record

ReviewNature reviews. Neurology2020

Neuromyelitis optica spectrum disorders and pregnancy: therapeutic considerations.

Yang Mao-Draayer, Sandra Thiel, Elizabeth A Mills, Tanuja Chitnis, Michelle Fabian, Ilana Katz Sand, M Isabel Leite, Sven Jarius, Kerstin Hellwig

Registry-linked trialAbstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Neurology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07653984 (Cohort Study on Neuroimmune Diseases in the Reproductive Age), which is not on this map. Cited by 40 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 5 pooled it
5.1field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT07653984 recruitingnot on this mapstarted 2024, after this paper: background citation

Cohort Study on Neuroimmune Diseases in the Reproductive Age

TypeobservationalSponsorThird Affiliated Hospital, Sun Yat-Sen UniversityRan2024 to 2030Enrolled100ConditionsNeuromyelitis Optica Spectrum Disorders (NMOSD), Multiple Sclerosis, Autoimmune Encephalitis, Myasthenia Gravis
3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 5 syntheses or guidelines pooled it, 96 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 3 countries.

Yang Mao-Draayer *Department of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.
Sandra Thiel *Department of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany.
Elizabeth A MillsDepartment of Neurology, University of Michigan Medical School, Ann Arbor, MI, USA.
Tanuja ChitnisDepartment of Neurology, Brigham and Women's Hospital and Massachusetts General Hospital, Boston, MA, USA.ORCID http://orcid.org/0000-0002-9897-4422
Michelle FabianDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
Ilana Katz SandDepartment of Neurology, Icahn School of Medicine at Mount Sinai, New York, NY, USA.
M Isabel LeiteNuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
Sven JariusMolecular Neuroimmunology Group, Department of Neurology, University of Heidelberg, Heidelberg, Germany.
Kerstin HellwigDepartment of Neurology, St. Josef-Hospital, Ruhr-University Bochum, Bochum, Germany. k.hellwig@klinikum-bochum.de.ORCID http://orcid.org/0000-0003-4467-9011
Icahn School of Medicine at Mount Sinai · USSt. Josef-Hospital · DEUniversity of Michigan · USBrigham and Women's Hospital · USHeidelberg University · DEUniversity of Oxford · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neuromyelitis optica spectrum disorders (NMOSD) are a type of neurological autoimmune disease characterized by attacks of CNS inflammation that are often severe and predominantly affect the spinal cord and optic nerve. The majority of individuals with NMOSD are women, many of whom are of childbearing age. Although NMOSD are rare, several small retrospective studies and case reports have indicated that pregnancy can worsen disease activity and might contribute to disease onset. NMOSD disease activity seems to negatively affect pregnancy outcomes. Moreover, some of the current NMOSD treatments are known to pose risks to the developing fetus and only limited safety data are available for others. Here, we review published studies regarding the relationship between pregnancy outcomes and NMOSD disease activity. We also assess the risks associated with using disease-modifying therapies for NMOSD during the course of pregnancy and breastfeeding. On the basis of the available evidence, we offer recommendations regarding the use of these therapies in the course of pregnancy planning in individuals with NMOSD.

Indexed as

Abnormalities, Drug-InducedAbortion, SpontaneousAdultFemaleHumansImmunologic FactorsNeuromyelitis OpticaObstetric Labor ComplicationsPre-EclampsiaPregnancyImmunologic Factors

Identifiers

PMID32080393
OpenAlexW3008159876

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.