Observational studyJournal of perinatology : official journal of the California Perinatal Association2020
The effect of patent ductus arteriosus on coronary artery blood flow in premature infants: a prospective observational pilot study.
Observational study in Journal of perinatology : official journal of the California Perinatal Association, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
11 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.
- Threshold to initiate chest compressions for bradycardia at birth: A narrative review.Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Cardiac biomarkers in term newborns with common pathological conditions during the first 24 hours postpartum.Biochemia medica · 2025Article
- Outcomes of CDH patients receiving PDA ligation: a propensity score matched analysis.Pediatric surgery international · 2025Article
- Serum Biomarkers in Patent Ductus Arteriosus in Preterm Infants: A Narrative Review.Biomedicines · 2025Review
- PDA management strategies and pulmonary hypertension in extreme preterm infants with bronchopulmonary dysplasia.Pediatric research · 2025Observational
- Doppler Ultrasonographic Assessment of Abdominal Aortic Flow to Evaluate the Hemodynamic Relevance of Left-to-Right Shunting Patent Ductus Arteriosus in Dogs.Animals : an open access journal from MDPI · 2024Article
- Preductal Hemodynamic Redistribution in Preterm Infants with Patent Ductus Arteriosus.Case reports in pediatrics · 2024Article
- Should we "eliminate" PDA shunt in preterm infants? A narrative review.Frontiers in pediatrics · 2024Review
- Objective Assessment of Physiologic Alterations Associated With Hemodynamically Significant Patent Ductus Arteriosus in Extremely Premature Neonates.Frontiers in pediatrics · 2021Review
- Ductal steal: does it affect pre-ductal arteries.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
- Ductal steal: does it affect pre-ductal arteries.Journal of perinatology : official journal of the California Perinatal Association · 2021Article
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Authors and funding
8 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo compare coronary flows between premature infants with and without hemodynamically significant patent ductus arteriosus (hsPDA) and to determine if coronary flow is influenced by medical PDA treatment.
designProspective, observational pilot study. Forty-three infants <32 weeks gestation underwent echocardiography when routinely indicated. Study group included infants with hsPDA requiring treatment. Comparison groups included infants with nonsignificant PDA and infants without PDA.
resultsThe study group (n = 13), compared with the comparison groups with nonsignificant PDA (n = 12) and without PDA (n = 18) had higher troponin levels (p = 0.003 and 0.004, respectively). In infants with hsPDA compared with infants with no PDA there was a significant increase in myocardial oxygen demand and decrease in left main coronary artery flow, with nonsignificant increase in cardiac output.
conclusionsDecrease in coronary artery flows and higher troponin values may suggest a "steal effect," not allowing to meet the elevated myocardial oxygen demand in infants with hsPDA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.