ArticleScientific reports2020
Evaluation of T1 relaxation time in prostate cancer and benign prostate tissue using a Modified Look-Locker inversion recovery sequence.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 19 papers.
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19 citing papers in PubMed, 35 citations in OpenAlex.
- Multiparametric magnetic resonance imaging (MRI) integrating amide proton transfer-weighted (APTw) imaging, synthetic MRI, and multiplexed sensitivity encoding diffusion-weighted imaging (MUSE DWI) in the diagnosis and grading of prostate cancer.Quantitative imaging in medicine and surgery · 2026Article
- Prostate Diffusion-weighted Imaging: Selecting the Optimal Repetition Time Using Synthetic Imaging Techniques.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2026Article
- Multi-Parameter Magnetic Resonance Spectroscopy in Cervix.NMR in biomedicine · 2026Article
- Quantitative Prostate MRI, From theAJR. American journal of roentgenology · 2025Review
- An Exploratory Study: Can Native T1 Mapping Differentiate Sarcoma from Benign Soft Tissue Tumors at 1.5 T and 3 T?Cancers · 2024Article
- Multiparametric approach with synthetic MR imaging for diagnosing salivary gland lesions.Japanese journal of radiology · 2024Article
- Short repetition time diffusion-weighted imaging improves visualization of prostate cancer.Japanese journal of radiology · 2024Article
- Technical note: hydrogel-based mimics of prostate cancer with matched relaxation, diffusion and kurtosis for validating multi-parametric MRI.Medical physics · 2024Article
- Rapid 3D TMagnetic resonance in medicine · 2023Article
- Use of machine learning to improve the estimation of conductivity and permittivity based on longitudinal relaxation time T1 in magnetic resonance at 7 T.Scientific reports · 2023Article
- Joint estimation of relaxation and diffusion tissue parameters for prostate cancer with relaxation-VERDICT MRI.Scientific reports · 2023Article
- Multicenter Repeatability and Reproducibility of MR Fingerprinting in Phantoms and in Prostatic Tissue.Magnetic resonance in medicine · 2022Article
- Developments in proton MR spectroscopic imaging of prostate cancer.Magma (New York, N.Y.) · 2022Review
- MR fingerprinting of the prostate.Magma (New York, N.Y.) · 2022Review
- Magnetic resonance fingerprinting in prostate cancer before and after contrast enhancement.The British journal of radiology · 2022Article
- Absolute choline tissue concentration mapping for prostate cancer localization and characterization using 3DMagnetic resonance in medicine · 2022Article
- Optimized bias and signal inference in diffusion-weighted image analysis (OBSIDIAN).Magnetic resonance in medicine · 2021Article
- Review
- Feasibility of Novel Three-Dimensional Magnetic Resonance Fingerprinting of the Prostate Gland: Phantom and Clinical Studies.Korean journal of radiology · 2021Article
Corrections and comments
- Erratum issued
Authors and funding
8 authors at 5 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose of this study was to evaluate the diagnostic performance of T1 relaxation time (T1) for differentiating prostate cancer (PCa) from benign tissue as well as high- from low-grade PCa. Twenty-three patients with suspicion for PCa were included in this prospective study. 3 T MRI including a Modified Look-Locker inversion recovery sequence was acquired. Subsequent targeted and systematic prostate biopsy served as a reference standard. T1 and apparent diffusion coefficient (ADC) value in PCa and reference regions without malignancy as well as high- and low-grade PCa were compared using the Mann-Whitney U test. The performance of T1, ADC value, and a combination of both to differentiate PCa and reference regions was assessed by receiver operating characteristic (ROC) analysis. T1 and ADC value were lower in PCa compared to reference regions in the peripheral and transition zone (p < 0.001). ROC analysis revealed high AUCs for T1 (0.92; 95%-CI, 0.87-0.98) and ADC value (0.97; 95%-CI, 0.94 to 1.0) when differentiating PCa and reference regions. A combination of T1 and ADC value yielded an even higher AUC. The difference was statistically significant comparing it to the AUC for ADC value alone (p = 0.02). No significant differences were found between high- and low-grade PCa for T1 (p = 0.31) and ADC value (p = 0.8). T1 relaxation time differs significantly between PCa and benign prostate tissue with lower T1 in PCa. It could represent an imaging biomarker for PCa.
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