ArticleScientific reports2020
Inhibition of Porphyromonas gulae and periodontal disease in dogs by a combination of clindamycin and interferon alpha.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 22 citations in OpenAlex.
- Neutrophil Extracellular Traps Promote the Formation of Canine Dental Calculus.Veterinary sciences · 2026Article
- Comparative inhibition of oral pathogens, biofilm formation, and inflammation-related responses by postbiotics fromJournal of oral microbiology · 2026Article
- Review
- Compositional Changes and Comparative Analysis of Oral Microbial Community During the Formation of Canine Dental Calculus.Animals : an open access journal from MDPI · 2025Article
- Bactericidal and Anti-Inflammatory Effects ofVeterinary sciences · 2025Article
- Type I interferon protects against bone loss in periodontitis by mitigating an interleukin (IL)-17-neutrophil axis.Life sciences · 2025Article
- Investigation of periodontal disease development and Porphyromonas gulae FimA genotype distribution in small dogs.Scientific reports · 2024Article
- Age-correlated changes in the canine oral microbiome.Frontiers in microbiology · 2024Article
- Host-microbe interactions in the nasal cavity of dogs with chronic idiopathic rhinitis.Frontiers in veterinary science · 2024Article
- Article
- Natural Antimicrobials Promote the Anti-Oxidative Inhibition of COX-2 Mediated Inflammatory Response in Primary Oral Cells Infected withAntioxidants (Basel, Switzerland) · 2023Article
- Presence of zoonotic black-pigmented periodontal pathogens in the oral microbiota of pet and stray cats.Veterinarni medicina · 2023Article
- Possible association ofFrontiers in veterinary science · 2023Article
- Assessment of Changes in the Oral Microbiome That Occur in Dogs with Periodontal Disease.Veterinary sciences · 2021Article
- Efficacy of FimA antibody and clindamycin in silkworm larvae stimulated withJournal of oral microbiology · 2021Article
- Periodontal disease is associated with cognitive dysfunction in aging dogs: A blinded prospective comparison of visual periodontal and cognitive questionnaire scores.Open veterinary journalArticle
Corrections and comments
- Erratum issued
Authors and funding
15 authors at 4 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Porphyromonas gulae is a major periodontal pathogen in dogs, which can be transmitted to their owners. A major virulence factor of P. gulae consists of a 41-kDa filamentous appendage (FimA) on the cell surface, which is classified into three genotypes: A, B, and C. Thus far, inhibition of periodontal disease in dogs remains difficult. The present study assessed the inhibitory effects of a combination of clindamycin and interferon alpha (IFN-α) formulation against P. gulae and periodontal disease. Growth of P. gulae was significantly inhibited by clindamycin; this inhibition had a greater effect on type C P. gulae than on type A and B isolates. In contrast, the IFN-α formulation inhibited the expression of IL-1β and COX-2 elicited by type A and B isolates, but not that elicited by type C isolates. Furthermore, periodontal recovery was promoted by the administration of both clindamycin and IFN-α formulation to dogs undergoing periodontal treatment; moreover, this combined treatment reduced the number of FimA genotypes in oral specimens from treated dogs. These results suggest that a combination of clindamycin and IFN-α formulation inhibit P. gulae virulence and thus may be effective for the prevention of periodontal disease induced by P. gulae.
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