Evidence map›Paper›PMID 32080224›Full record

ArticleScientific reports2020

Effect of bisphenol A on human neutrophils immunophenotype.

Wioletta Ratajczak-Wrona, Małgorzata Rusak, Karolina Nowak, Milena Dabrowska, Piotr Radziwon, Ewa Jablonska

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.9field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 30 citations in OpenAlex.

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  17. Sex-dependent dysregulation of human neutrophil responses by bisphenol A.Environmental health : a global access science source · 2021
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Wioletta Ratajczak-WronaDepartment of Immunology, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Bialystok, Poland. wioletta.ratajczak-wrona@umb.edu.pl.
Małgorzata RusakDepartment of Hematological Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Bialystok, Poland.
Karolina NowakDepartment of Immunology, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Bialystok, Poland.
Milena DabrowskaDepartment of Hematological Diagnostics, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Bialystok, Poland.
Piotr RadziwonRegional Centre for Transfusion Medicine, Bialystok, ul. M. Skłodowskiej - Curie 23, 15-950, Bialystok, Poland.
Ewa JablonskaDepartment of Immunology, Medical University of Bialystok, ul. Waszyngtona 15A, 15-269, Bialystok, Poland.
Medical University of Białystok · PL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Neutrophils (PMN) play a key role in eliciting congenital immune response. These cells are equipped with specific receptors that are located on the surface of their cell membrane. These receptors produce various signals which in turn help in the effective functioning of PMN. The activity of these cells may be modified by factors of endo- and exogenous origin, including xenoestrogens such as bisphenol A (BPA). The aim of this study was to evaluate the effect of BPA on the expression of CD11c, CD14, CD15, CD16, CD62L and CD284 compounds on the surface of neutrophils in women and men. The study material included PMN isolated from the whole blood. The cells were incubated in the presence of BPA and/or LPS. Flow cytometry technique was used to evaluate the expression of CD antigens. Studies of these receptors indicate that BPA, at a concentration corresponding to the serum level of this compound in healthy subjects as well as at higher doses, induces changes in the immunophenotype of PMN, which may lead to immunity disorders associated with the dysfunction of these cells. Moreover, the observed effects of xenoestrogen on the expression of CD11c, CD14, CD15, CD16, CD62L and CD284 differentiation markers on these cells are sex-independent.

Indexed as

AdultAntigens, CDBenzhydryl CompoundsBisphenol A CompoundsBlood DonorsFemaleFlow CytometryHumansImmunophenotypingMaleNeutrophilsPhenolsSex FactorsYoung AdultAntigens, CDBenzhydryl Compoundsbisphenol ABisphenol A CompoundsPhenols

Identifiers

PMID32080224
PMCPMC7033170
OpenAlexW3007888941

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.