ArticleScientific reports2020
c-di-GMP-related phenotypes are modulated by the interaction between a diguanylate cyclase and a polar hub protein.
Article in Scientific reports, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 28 citations in OpenAlex.
- Review
- The polar landscape of bacterial pathogens and predators.Current opinion in microbiology · 2026Review
- Article
- Co-Expression of PA0290 and PelD EnhancesMicroorganisms · 2026Article
- Redundancy maintains microbial ecosystem functional potential despite taxonomic shifts between serpentine and nonserpentine soils.Microbial genomics · 2026Article
- Functional characterization of the polar organizer protein FimV inJournal of bacteriology · 2026Article
- Genetic analysis of flagellar-mediated surface sensing byJournal of bacteriology · 2025Article
- Spatio-genetically coordinated TPR domain-containing proteins modulate c-di-GMP signaling in Vibrio vulnificus.PLoS pathogens · 2025Article
- Genetic Dissection of Cyclic di-GMP Signalling in Pseudomonas aeruginosa via Systematic Diguanylate Cyclase Disruption.Microbial biotechnology · 2025Article
- c-di-GMP phosphodiesterase ProE interacts with quorum sensing protein PqsE to promote pyocyanin production inmSphere · 2025Article
- Bacterial respiratory inhibition triggers dispersal ofApplied and environmental microbiology · 2023Article
- Biofilm Signaling, Composition and Regulation inJournal of microbiology and biotechnology · 2023Review
- Characterization of a soluble library of themicroLife · 2023Article
- Polarity of c-di-GMP synthesis and degradation.microLife · 2023Review
- Identification of the core c-di-GMP turnover proteins responsible for root colonization ofiScience · 2022Article
- GGDEF domain as spatial on-switch for a phosphodiesterase by interaction with landmark protein HubP.NPJ biofilms and microbiomes · 2022Article
- Cyclic dinucleotides mediate bacterial immunity by dinucleotide cyclase inFrontiers in microbiology · 2022Review
- Phenotypic and integrated analysis of a comprehensiveFrontiers in microbiology · 2022Article
- Differential ligand-selective control of opposing enzymatic activities within a bifunctional c-di-GMP enzyme.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
Corrections and comments
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Authors and funding
11 authors at 4 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
c-di-GMP is a major player in the switch between biofilm and motile lifestyles. Several bacteria exhibit a large number of c-di-GMP metabolizing proteins, thus a fine-tuning of this nucleotide levels may occur. It is hypothesized that some c-di-GMP metabolizing proteins would provide the global c-di-GMP levels inside the cell whereas others would maintain a localized pool, with the resulting c-di-GMP acting at the vicinity of its production. Although attractive, this hypothesis has yet to be demonstrated in Pseudomonas aeruginosa. We found that the diguanylate cyclase DgcP interacts with the cytosolic region of FimV, a polar peptidoglycan-binding protein involved in type IV pilus assembly. Moreover, DgcP is located at the cell poles in wild type cells but scattered in the cytoplasm of cells lacking FimV. Overexpression of dgcP leads to the classical phenotypes of high c-di-GMP levels (increased biofilm and impaired motilities) in the wild-type strain, but not in a ΔfimV background. Therefore, our findings suggest that DgcP activity is regulated by FimV. The polar localization of DgcP might contribute to a local c-di-GMP pool that can be sensed by other proteins at the cell pole, bringing to light a specialized function for a specific diguanylate cyclase.
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