Observational studyMedicine2020
β2-microglobulin is an independent indicator of acute kidney injury and outcomes in patients with intracerebral hemorrhage.
Observational study in Medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 1 of them a synthesis that pooled it.
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Who cites it
17 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.
- Acute kidney injury incidence and mortality following spontaneous intracerebral hemorrhage: a systematic review and meta-analysis.Frontiers in medicine · 2026Pooled it
- A prospective pilot study of kidney-specific biomarkers to detect acute kidney injury after cytoreduction and hyperthermic intraperitoneal chemotherapy.Asian biomedicine : research, reviews and news · 2024Article
- Serum β2-microglobulin as an independent risk factor for mortality in patients with acute respiratory distress syndrome caused by bacterial infection.Scientific reports · 2024Article
- Beta 2-microglobulin is an independent risk marker of acute kidney injury in adult patients with hemophagocytic lymphohistiocytosis.Journal of nephrology · 2024Observational
- Serum beta2-microglobulin and peripheral blood eosinophils for the assessment of severity and prognosis with omicron variant COVID-19 infection.Frontiers in molecular biosciences · 2024Article
- Preliminary investigation of the effect of non-cardiac surgery on intraoperative islet and renal function: a single-center prospective cohort study.Frontiers in medicine · 2024Article
- Acute kidney injury after intracerebral hemorrhage: a mini review.Frontiers in medicine · 2024Review
- Biomarkers to Predict Multiorgan Distress Syndrome and Acute Kidney Injury in Critically Ill Surgical Patients.Medicina (Kaunas, Lithuania) · 2023Article
- [Dexmedetomidine can not reduce the incidence of acute and chronic kidney disease after laparoscopic radical nephrectomy: a propensity score matching-based analysis].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2023Review
- Elevated serum beta-2 microglobulin level predicts short-term poor prognosis of patients withFrontiers in cellular and infection microbiology · 2023Article
- Dehydration Status Aggravates Early Renal Impairment in Children: A Longitudinal Study.Nutrients · 2022Article
- The Perspectives of Biomarkers in Predicting the Survival of the Renal Graft.Frontiers in pediatrics · 2022Review
- Effect of Race-Ethnicity and CT Angiography on Renal Injury During Blood Pressure Treatment for Intracerebral Hemorrhage.Neurocritical care · 2021Article
- The effect of Bailing capsules combined with losartan to treat diabetic glomerulosclerosis and the combination's effect on blood and urine biochemistry.American journal of translational research · 2021Article
- Analysis of Risk Factors for Perioperative Acute Kidney Injury and Management Strategies.Frontiers in medicine · 2021Review
- Inflammatory Response and Oxidative Stress as Mechanism of Reducing Hyperuricemia ofOxidative medicine and cellular longevity · 2021Article
- Role of Urinary Beta 2 Microglobulin and Kidney Injury Molecule-1 in Predicting Kidney Function at One Year Following Acute Kidney Injury.International journal of nephrology and renovascular disease · 2021Article
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Acute kidney injury (AKI), a serious complication in critically ill patients, is associated with poor clinical outcomes. We explored the hypothesis that β2-microglobulin (β2-MG) is an independent indicator of AKI development and outcomes in patients with intracerebral hemorrhage (ICH) in the neurosurgical intensive care unit (NICU).Patients with ICH (n = 403) admitted to the NICU of Zhongnan Hospital, Wuhan University, between January 1, 2015 and December 31, 2016 were prospectively enrolled in this single-center, observational study. The primary outcome was the incidence of AKI, secondary outcomes were in-hospital mortality and 1-year mortality (from time of admission).The overall AKI incidence, in hospital, was 35.2%; patients were diagnosed with stage 1 (22.1%), 2 (5.7%), and 3 (7.4%) AKI. β2-MG levels predicted AKI with an area under the curve of 0.712 (95% confidence interval [CI], 0.652-0.772) and a cut-off of 2026.85 μg/L (sensitivity, 57.5%; specificity, 79.4%). Compared with the group having lower β2-MG values, the group with higher values (β2-MG >2123.50 μg/L) had significantly higher risks of AKI (odds ratio, 2.606; 95% CI, 1.315-5.166), in-hospital mortality (hazard ratio [HR], 2.548; 95% CI, 1.318-4.924), and 1-year mortality (HR, 3.161; 95% CI, 1.781-5.611) in adjusted analyses.β2-MG levels predict AKI development and outcomes in patients with ICH in the NICU.
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