Evidence map›Paper›PMID 32079974›Full record

ArticleJournal of pediatric gastroenterology and nutrition2020

Acute Gastroenteritis in Children of the World: What Needs to Be Done?

Alfredo Guarino, Juliet Aguilar, James Berkley, Ilse Broekaert, Rodrigo Vazquez-Frias, Lori Holtz, Andrea Lo Vecchio, Toufik Meskini, Sean Moore, Juan F Rivera Medina and 4 more

Open access · greenAbstract read
In one paragraph

Article in Journal of pediatric gastroenterology and nutrition, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
40citing papers in PubMed, 1 pooled it
0.6field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

40 citing papers in PubMed, 1 synthesis or guideline pooled it, 57 citations in OpenAlex.

  1. Pooled it
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  7. Article
  8. Prevalence of astrovirus-associated gastroenteritis among hospitalized pediatric patients in Asia: A systematic review and meta-analysis.Indian journal of gastroenterology : official journal of the Indian Society of Gastroenterology · 2026
    Review
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  12. The combination ofFrontiers in microbiology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 13 institutions in 12 countries.

Alfredo GuarinoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy (ESPGHAN).
Juliet AguilarDepartment of Pediatrics, University of the Philippines Manila - Philippine General Hospital, Institute of Pediatrics and Child Health, St. Luke's Medical Center, Quezon City, Philippines (APPSGHAN).
James BerkleyDepartment of Paediatric Infectious Diseases, KEMRI/Wellcome Trust Research Programme, Kilifi, Kenya.
Ilse BroekaertUniversity Children's Hospital, Cologne, Germany (ESPGHAN).
Rodrigo Vazquez-FriasHospital Infantil de México Federico Gomez, Mexico City, Mexico (LASPGHAN).
Lori HoltzDepartment of Pediatrics, Washington University School of Medicine, St. Louis, MO (NASPGHAN).
Andrea Lo VecchioDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy (ESPGHAN).
Toufik MeskiniFaculty of Medicine and pharmacy of Rabat, Rabat Children's Hospital, Mohammed V University of Rabat, Rabat, Morocco (PASPGHAN).
Sean MooreDivision of Pediatric Gastroenterology, Hepatology, and Nutrition, Department of Pediatrics, University of Virginia, Charlottesville, VA (NASPGHAN).
Juan F Rivera MedinaUniversidad Nacional Mayor de San Marcos and Universidad Peruana Cayetano Heredia, Hospital del Niño, National Institute of Pediatrics, Lima, Peru (LASPGHAN).
Bhupinder SandhuDepartment of Paediatric Gastroenterology and Nutrition, Bristol Royal Hospital for Children, Bristol, UK (CAPGAN).
Andrea SmarrazzoDepartment of Translational Medical Science, Section of Pediatrics, University of Naples Federico II, Naples, Italy (ESPGHAN).
Hania SzajewskaDepartment of Paediatrics, The Medical University of Warsaw, Warsaw, Poland (ESPGHAN).
Suporn TreepongkarunaDepartment of Pediatrics, Faculty of Medicine, Ramathibodi Hospital, Mahidol University, Bangkok, Thailand (APPSGHAN).
University of Naples Federico II · ITAngkor Hospital for Children · KHBristol Royal Hospital for Children · GBFederico II University Hospital · ITHospital Infantil de México Federico Gómez · MXMedical University of Warsaw · PLMohammed V University · MANational University of San Marcos · PERamathibodi Hospital · THSt. Luke's Medical Center · PHUniversity Hospital Cologne · DEUniversity of Virginia · USWashington University in St. Louis · US

Funding

Wellcome Trust 203077
6 · The paper itself

Abstract

The incidence of gastroenteritis has greatly reduced due to improved hygiene conditions in developing countries and the use of rotavirus vaccine. Still thousands of children, however, die from gastroenteritis, most of them in poor countries. Yet gastroenteritis management is simple, inexpensive, and effective and is largely the same all over the world. Universal guidelines for gastroenteritis guide the management and include simple interventions put forward early in the course of the disease. Treatment includes rehydration, continuing oral feeding, and anti-infective drugs in selected clinical conditions related to the symptoms or to host-related risk, and possible additional drug treatment to reduce the duration and severity of symptoms. There may be minor geographical differences in the treatment applied due to health care organizations that do not substantially change the standard universal recommendations. Prevention is recommended with sanitation interventions and rotavirus universal immunization. Implementation of those interventions through educational initiatives and local programs in target areas are needed. A series of recommendations for interventions, education, and research priorities are included here with the aim of reducing the burden of gastroenteritis, to be pursued by scientists, physicians, policy makers, and stakeholders involved. They include the need of recommendations for the management of gastroenteritis in malnourished children, in those with chronic conditions, in neonates, and in emergency settings. A reference system to score dehydration, the definition of optimal composition of rehydration solution and the indications for anti-infective therapy are also included. Rotavirus immunization should be actively promoted, and evidence-based guidelines should be universally implemented. Research priorities are also indicated.

Indexed as

GastroenteritisRotavirus InfectionsRotavirus VaccinesChildEmergency Service, HospitalFluid TherapyHumansInfantInfant, NewbornVaccinationRotavirus Vaccines

Identifiers

PMID32079974
PMCPMC7613312
OpenAlexW3007723298

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.