Evidence map›Paper›PMID 32079916›Full record

Trial reportMedicine and science in sports and exercise2020

Leucine Supplementation Has No Further Effect on Training-induced Muscle Adaptations.

Isabel Thomazi DE Andrade, Bruno Gualano, Victoria Hevia-Larraín, Juarez Neves-Junior, Monique Cajueiro, Felipe Jardim, Rodrigo Leite Gomes, Guilherme Giannini Artioli, Stuart M Phillips, Patrícia Campos-Ferraz and 1 more

Erratum issuedAbstract readRandomized Controlled Trial
PubMed Publisher
In one paragraph

Trial report in Medicine and science in sports and exercise, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.3field-weighted citation impact, top 23% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 21 citations in OpenAlex.

  1. Trial
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  5. Review
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  9. Corrigendum.Medicine and science in sports and exercise · 2021
    Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Isabel Thomazi DE Andrade
Bruno GualanoApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Victoria Hevia-LarraínApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Juarez Neves-JuniorApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Monique CajueiroApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Felipe JardimApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Rodrigo Leite GomesApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Guilherme Giannini ArtioliApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Stuart M PhillipsDepartment of Kinesiology, McMaster University, Hamilton, CANADA.
Patrícia Campos-FerrazFaculty of Applied Sciences, University of Campinas, Limeira, São Paulo, BRAZIL.
Hamilton RoschelApplied Physiology and Nutrition Research Group, University of São Paulo, São Paulo, BRAZIL.
Universidade de São Paulo · BRMcMaster University · CAUniversidade Estadual de Campinas (UNICAMP) · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionSeveral acute studies have suggested that leucine is a key amino acid to drive muscle protein synthesis. However, there are very few studies on the long-term effects of leucine supplementation on resistance training (RT)-induced gains in muscle mass and strength. We sought to determine the impact of 10 g of leucine on muscle mass and strength in response to RT in healthy young men.

methodsTwenty-five, resistance-trained men (27 ± 5 yr; 78.4 ± 11.6 kg; 24.8 ± 3.0 kg·m) consuming 1.8 ± 0.4 g protein·kg·d, were randomly assigned to receive 2 × 5 g·d supplementation of either free leucine (LEU n = 12) or alanine (PLA n = 13) while undergoing a supervised 12-wk, twice-weekly lower-limb RT program. One-repetition maximum (leg-press 1RM) and muscle cross-sectional area (mCSA) of the vastus lateralis were determined before (PRE) and after (POST) the intervention. Additionally, three 24-h dietary recalls were also performed at PRE and POST.

resultsProtein intake was roughly double that of the RDA in both groups and remained unchanged across time with no differences detected between groups. Similar increases were observed between groups in leg-press 1RM (LEU, 19.0% ± 9.4% and PLA, 21.0% ± 10.4%, P = 0.31) and mCSA (LEU, 8.0% ± 5.6% and PLA, 8.4% ± 5.1%, P = 0.77).

conclusionsHigh-dose leucine supplementation did not enhance gains in muscle strength and mass after a 12-wk RT program in young resistance-trained males consuming adequate amounts of dietary protein.

Indexed as

Adaptation, PhysiologicalDietary SupplementsMuscle StrengthResistance TrainingAdultDietary ProteinsDouble-Blind MethodHumansLeucineLower ExtremityMaleMuscle ProteinsMuscle, SkeletalUltrasonographyYoung AdultDietary ProteinsLeucineMuscle Proteins

Identifiers

PMID32079916
OpenAlexW3008908337

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.