ArticleScience (New York, N.Y.)2020
A cell atlas of human thymic development defines T cell repertoire formation.
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Article in Science (New York, N.Y.), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 483 papers.
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483citing papers in PubMed
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483 citing papers in PubMed, 694 citations in OpenAlex.
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- The Thymic Microenvironment Shapes Age-Related Qualitative Changes in the TCR Repertoire.Aging cell · 2026Article
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- Decoding Spatial Heterogeneity and Multi-Omics Regulation with Hierarchical Graph Learning.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Association between prenatal exposure to acid-suppressive medications and subsequent risk of autoimmune diseases in offspring: a nationwide birth cohort study in South Korea.World journal of pediatrics : WJP · 2026Article
- Age dependent collective trafficking of tissue resident T cells in zebrafish.bioRxiv : the preprint server for biology · 2026Article
423 more citing papers are in PubMed but not listed here.
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Authors and funding
42 authors at 9 institutions in 2 countries.
Jong-Eun ParkWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-1687-2423
Rachel A BottingBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0001-9595-4605
Cecilia Domínguez CondeWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-8684-4655
Dorin-Mirel PopescuBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Marieke LavaertFaculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium.ORCID 0000-0002-5814-7940
Daniel J KunzWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0003-3597-6591
Issac GohBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-6397-3518
Emily StephensonBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-4244-4019
Roberta RagazziniEpithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Elizabeth TuckWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-1837-7549
Anna Wilbrey-ClarkWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Kenny RobertsWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-6155-0821
Veronika R KedlianWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-6563-0829
John R FerdinandMolecular Immunity Unit, Department of Medicine, University of Cambridge, MRC Laboratory of Molecular Biology, Cambridge CB2 0QQ, UK.ORCID 0000-0003-0936-0128
Xiaoling HeJohn van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.
Simone WebbBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0003-3058-8952
Daniel MaunderBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Niels VandammeData Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.ORCID 0000-0001-6582-0040
Krishnaa T MahbubaniDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0002-1327-2334
Krzysztof PolanskiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-2586-9576
Lira MamanovaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0003-1463-8622
Liam BoltWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-7293-0774
David CrosslandBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Fabrizio de RitaDepartment of Adult Congenital Heart Disease and Paediatric Cardiology/Cardiothoracic Surgery, Freeman Hospital, Newcastle Hospitals NHS Foundation Trust, Newcastle upon Tyne NE2 4LP, UK.ORCID 0000-0002-4717-4644
Andrew FullerBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Andrew FilbyBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.
Gary ReynoldsBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-8142-8708
David DixonBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0003-4393-1801
Kourosh Saeb-ParsyDepartment of Surgery, University of Cambridge and NIHR Cambridge Biomedical Research Centre, Cambridge CB2 0QQ, UK.ORCID 0000-0002-0633-3696
Steven LisgoBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0001-5186-3971
Deborah HendersonBiosciences Institute, Faculty of Medical Sciences, Newcastle University, Newcastle upon Tyne NE2 4HH, UK.ORCID 0000-0002-2705-5998
Roser Vento-TormoWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-9870-8474
Omer A BayraktarWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.
Roger A BarkerJohn van Geest Centre for Brain Repair, University of Cambridge, Cambridge CB2 0PY, UK.ORCID 0000-0001-8843-7730
Kerstin B MeyerWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0001-5906-1498
Yvan SaeysData Mining and Modeling for Biomedicine, VIB Center for Inflammation Research, Ghent, Belgium.ORCID 0000-0002-0415-1506
Paola BonfantiEpithelial Stem Cell Biology and Regenerative Medicine Laboratory, Francis Crick Institute, London NW1 1AT, UK.
Sam BehjatiWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-6600-7665
Menna R ClatworthyWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK.ORCID 0000-0002-3340-9828
Tom TaghonFaculty of Medicine and Health Sciences, Department of Diagnostic Sciences, Ghent University, 9000 Ghent, Belgium. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.ORCID 0000-0002-5781-0288
Muzlifah HaniffaWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.ORCID 0000-0002-3927-2084
Sarah A TeichmannWellcome Sanger Institute, Wellcome Genome Campus, Hinxton, Cambridge CB10 1SA, UK. m.a.haniffa@newcastle.ac.uk tom.taghon@ugent.be st9@sanger.ac.uk.ORCID 0000-0002-6294-6366
Wellcome Sanger Institute · GBNewcastle University · GBUniversity of Cambridge · GBGhent University · BEGhent University Hospital · BEGreat Ormond Street Hospital · GBMRC Laboratory of Molecular Biology · GBNewcastle upon Tyne Hospitals NHS Foundation Trust · GBWellcome/MRC Cambridge Stem Cell Institute · GB
Funding
European Research Council 646794Medical Research Council MC_PC_12009Medical Research Council MC_PC_17180Medical Research Council MC_PC_17230Medical Research Council MR/R006237/1Medical Research Council MR/S035842/1Wellcome Trust 221052
Abstract
The thymus provides a nurturing environment for the differentiation and selection of T cells, a process orchestrated by their interaction with multiple thymic cell types. We used single-cell RNA sequencing to create a cell census of the human thymus across the life span and to reconstruct T cell differentiation trajectories and T cell receptor (TCR) recombination kinetics. Using this approach, we identified and located in situ CD8αα
Indexed as
Atlases as TopicCell DifferentiationCD8-Positive T-LymphocytesDendritic CellsFibroblastsHumansReceptors, Antigen, T-CellRNA-SeqSingle-Cell AnalysisThymus GlandReceptors, Antigen, T-Cell
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