Evidence map›Paper›PMID 32079677›Full record

ArticleThe Journal of biological chemistry2020

Paraoxonase 3 functions as a chaperone to decrease functional expression of the epithelial sodium channel.

Shujie Shi, Nicolas Montalbetti, Xueqi Wang, Brittney M Rush, Allison L Marciszyn, Catherine J Baty, Roderick J Tan, Marcelo D Carattino, Thomas R Kleyman

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in The Journal of biological chemistry, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 12 citations in OpenAlex.

  1. The scaffold protein IQGAP1 regulates the epithelial NaThe Journal of biological chemistry · 2025
    Article
  2. Article
  3. Paraoxonase 3 regulates the pore-forming α subunit of the large-conductance KBiochimica et biophysica acta. Molecular cell research · 2025
    Article
  4. Article
  5. Epithelial NaComprehensive Physiology · 2024
    Review
  6. Article
  7. Article
  8. The Epithelial Sodium Channel-An Underestimated Drug Target.International journal of molecular sciences · 2023
    Review
  9. Article
  10. Paraoxonase 2 is an ER chaperone that regulates the epithelial NaAmerican journal of physiology. Cell physiology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 2 countries.

Shujie ShiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261 shs117@pitt.edu.
Nicolas MontalbettiRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Xueqi WangRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Brittney M RushRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Allison L MarciszynRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Catherine J BatyRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Roderick J TanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Marcelo D CarattinoRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.
Thomas R KleymanRenal-Electrolyte Division, Department of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania 15261.ORCID 0000-0002-2413-5415
University of Pittsburgh · USCentral South University · CN

Funding

Single Nephron and MetabolomicsP30DK079307 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KLEYMAN, THOMAS R · 2008 to 2022
$13.4M
Regulation of K and H secretion by intercalated cellsR01DK038470 · NIDDK · YESHIVA UNIVERSITY · PI HUGHEY, REBECCA P, KLEYMAN, THOMAS R · 1994 to 2022
$7.7M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Regulation of ENaC/degenerin channels by mechanical forcesK01DK103834 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2014 to 2018
$688k
Integrated perfusion and confocal imaging systemS10OD021627 · OD · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI WEISZ, ORA A · 2016 to 2016
$479k
Regulation of ENaC expression by paraoxonase-2R03DK119752 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SHI, SHUJIE · 2019 to 2020
$235k
NHLBI NIH HHS R01 HL147818NIDDK NIH HHS K01 DK103834NIDDK NIH HHS P30 DK079307NIDDK NIH HHS R01 DK038470NIDDK NIH HHS R03 DK119752NIH HHS S10 OD021627
6 · The paper itself

Abstract

The paraoxonase (PON) family comprises three highly conserved members: PON1, PON2, and PON3. They are orthologs of

Indexed as

AnimalsAryldialkylphosphataseCell MembraneEpithelial Sodium ChannelsIon TransportMiceMolecular ChaperonesOocytesRatsSignal TransductionSodiumThyroid GlandXenopus laevisAryldialkylphosphataseEpithelial Sodium ChannelsMolecular ChaperonesPON3 protein, mouseSodiumaldosteronechaperonedegenerinepithelial sodium channel (ENaC)hypertensionkidneyMEC-6PON3

Identifiers

PMID32079677
PMCPMC7152764
OpenAlexW3008022774

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.