Evidence map›Paper›PMID 32079657›Full record

ArticleJournal of cell science2020

Distinct roles of two eIF4E isoforms in the germline of

Hayden P Huggins, Jacob S Subash, Hamilton Stoffel, Melissa A Henderson, Jenna L Hoffman, David S Buckner, Madhu S Sengupta, Peter R Boag, Myon-Hee Lee, Brett D Keiper

Open access · bronzeAbstract read
In one paragraph

Article in Journal of cell science, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
1.9field-weighted citation impact, top 17% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. SLBP-independent control of maternal histone mRNA.bioRxiv : the preprint server for biology · 2026
    Article
  3. Identification of eIF4ET binding partners inmicroPublication biology · 2026
    Article
  4. Review
  5. eIF4E assembly intobioRxiv : the preprint server for biology · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Article
  13. Article
  14. Selective Translation of Maternal mRNA by eIF4E1B Controls Oocyte to Embryo Transition.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2023
    Article
  15. Review
  16. Article
  17. Review
  18. The role of RNA-binding proteins in orchestrating germline development inFrontiers in cell and developmental biology · 2022
    Review
  19. Sex Determination in Nematode Germ Cells.Sexual development : genetics, molecular biology, evolution, endocrinology, embryology, and pathology of sex determination and differentiation · 2022
    Review
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 2 countries.

Hayden P HugginsDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Jacob S SubashDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Hamilton StoffelDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Melissa A HendersonDepartment of Molecular Sciences, DeBusk College of Osteopathic Medicine, Lincoln Memorial University, Harrogate, TN 37752, USA.
Jenna L HoffmanDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
David S BucknerDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.
Madhu S SenguptaMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.
Peter R BoagMonash Biomedicine Discovery Institute and Department of Biochemistry and Molecular Biology, Monash University, Clayton, VIC 3800, Australia.ORCID 0000-0002-0889-0859
Myon-Hee LeeDepartment of Internal Medicine, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA.ORCID 0000-0001-9020-2391
Brett D KeiperDepartment of Biochemistry and Molecular Biology, Brody School of Medicine at East Carolina University, Greenville, NC 27834, USA keiperb@ecu.edu.ORCID 0000-0002-8621-9825
East Carolina University · USDiscovery Institute · USLincoln Memorial University · US

Funding

Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Ann E. Rougvie · 2012 to 2026
$7.5M
Action Mechanisms of Resveratrol in Somatic Longevity and Reproductive SystemR15AG060373 · NIA · EAST CAROLINA UNIVERSITY · PI LEE, MYON HEE · 2018 to 2019
$459k
NIA NIH HHS R15 AG060373NIH HHS P40 OD010440
6 · The paper itself

Abstract

Germ cells use both positive and negative mRNA translational control to regulate gene expression that drives their differentiation into gametes. mRNA translational control is mediated by RNA-binding proteins, miRNAs and translation initiation factors. We have uncovered the discrete roles of two translation initiation factor eIF4E isoforms (IFE-1, IFE-3) that bind 7-methylguanosine (m7G) mRNA caps during

Indexed as

Caenorhabditis elegansCaenorhabditis elegans ProteinsAnimalsEukaryotic Initiation Factor-4EMaleProtein IsoformsRNA-Binding ProteinsRNA, MessengerCaenorhabditis elegans ProteinsEukaryotic Initiation Factor-4EPGL-1 protein, C elegansProtein IsoformsRNA-Binding ProteinsRNA, Messenger4EBPeIF4EGametogenesisGermline sex determinationmRNA translational controlPolysomes

Identifiers

PMID32079657
PMCPMC7132772
OpenAlexW3006801072

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.