ArticleBMJ open diabetes research & care2020
Association of prestroke glycemic status with stroke mortality.
Article in BMJ open diabetes research & care, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.
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Who cites it
10 citing papers in PubMed, 20 citations in OpenAlex.
- Association between prediabetes and higher risk of mortality following acute ischemic stroke: A meta-analysis.World journal of diabetes · 2026Article
- Predictive Value of the Lowest Serum Albumin Level During Hospitalization in Patients With Intracerebral Hemorrhage.Neurology research international · 2026Article
- Risk of postoperative major adverse cerebrovascular events in patients with spontaneous intracranial hematoma stratified by type 2 diabetes mellitus.Frontiers in human neuroscience · 2025Article
- Impact of type 2 diabetes mellitus on hematoma expansion and clinical outcomes in patients with spontaneous intracranial hematoma.Frontiers in surgery · 2025Article
- Review
- Qixue Shuangbu decoction and acupuncture combined with Western medicine in acute severe stroke patients.World journal of clinical cases · 2023Article
- High serum complement component C4 as a unique predictor of unfavorable outcomes in diabetic stroke.Metabolic brain disease · 2021Article
- Pre-diabetes is a predictor of short-term poor outcomes after acute ischemic stroke using IV thrombolysis.BMC neurology · 2021Article
- Relationship Between Glycosylated Hemoglobin and Short-Term Mortality of Spontaneous Intracerebral Hemorrhage.Frontiers in neurology · 2021Article
- Nationwide trends in stroke hospitalizations among patients with prediabetes.International journal of cardiology. Heart & vasculature · 2020Article
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Authors and funding
6 authors at 2 institutions in 1 country.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe role of diabetes as a predictor of mortality after stroke remains uncertain, and there are very few data for pre-diabetes. This study investigated the association of pre-diabetes and diabetes with 30-day and 1-year mortality after ischemic stroke (IS) and primary intracerebral hemorrhage (ICH). RESEARCH DESIGN AND
methodsBetween 2006 and 2013, 2076 patients with IS and 586 patients with ICH (median age 79) were admitted to hospital within 24 hours after stroke onset and were treated in a stroke unit, where they underwent measurement of glycated hemoglobin (HbA1c). Diabetes was retrospectively defined based on medical history, diagnosis during hospital stay or HbA1c ≥6.5% (48 mmol/mol). Pre-diabetes was defined as HbA1c of 5.7%-6.4% (39-47 mmol/mol). Stroke severity was measured using the National Institutes of Health Stroke Scale (NIHSS). HRs were used to test the association of pre-diabetes and diabetes with 30-day and 1-year mortality after stroke onset.
resultsAmong patients with IS, 830 had pre-diabetes and 632 had diabetes; 280 died within 30 days and the other 77 within 1 year. Among patients with ICH, 106 had pre-diabetes and 56 had diabetes; 150 died within 30 days and the other 92 within 1 year. In both stroke subtypes, pre-diabetes and diabetes were associated with higher 30-day mortality. In IS, however, the association was limited to patients with prestroke disability and very severe stroke. At NIHSS 25, HR was 1.58 (95% CI 1.07 to 2.35) for pre-diabetes and 1.67 (95% CI 1.14 to 2.46) for diabetes compared with normoglycemia. In ICH, the association was limited to women for pre-diabetes (HR 1.93, 95% CI 1.15 to 3.24) and to men for diabetes (HR 1.78, 95% CI 1.02 to 3.12). Prestroke glycemic status was unrelated to 1-year mortality.
conclusionsBoth pre-diabetes and diabetes predict short-term mortality after acute stroke, but the association varies depending on both prestroke and stroke-related characteristics. These findings may explain the heterogeneous results obtained by previous studies.
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