Evidence map›Paper›PMID 32079538›Full record

ArticleBMC medicine2020

Anxiety and depression in children and adolescents with obesity: a nationwide study in Sweden.

Louise Lindberg, Emilia Hagman, Pernilla Danielsson, Claude Marcus, Martina Persson

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in BMC medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05675020 (Promote Healthy Lifestyle Behaviors for Adolescents With Mental Health Conditions), which is not on this map. Cited by 132 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
132citing papers in PubMed, 4 pooled it
26.7field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05675020 nacompletednot on this mapstarted 2022, after this paper: background citation

Promote Healthy Lifestyle Behaviors for Adolescents With Mental Health Conditions

TypeinterventionalSponsorFlorida State UniversityRan2022 to 2023Enrolled86ConditionsBehavioral / Psychiatric Disorder, Lifestyle, HealthyArmsZoom Intervention
3 · Its place in the literature

Who cites it

132 citing papers in PubMed, 4 syntheses or guidelines pooled it, 262 citations in OpenAlex.

  1. Clinically effective child change in family-based behavioral treatment for pediatric obesity: An individual participant mega-analysis.Health psychology : official journal of the Division of Health Psychology, American Psychological Association · 2026
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72 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Louise LindbergDivision of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Blickagången 6A Novum, 141 57, Stockholm, Sweden. louise.lindberg@ki.se.ORCID 0000-0002-9517-5000
Emilia HagmanDivision of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Blickagången 6A Novum, 141 57, Stockholm, Sweden.
Pernilla DanielssonDivision of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Blickagången 6A Novum, 141 57, Stockholm, Sweden.
Claude MarcusDivision of Pediatrics, Department of Clinical Science, Intervention and Technology, Karolinska Institutet, Blickagången 6A Novum, 141 57, Stockholm, Sweden.
Martina PerssonDepartment of Medicine, Solna, Clinical Epidemiology Unit, Karolinska Institutet, Stockholm, Sweden.
Karolinska Institutet · SE

Funding

Föreningen Mjölkdroppen 4-1200/2019Fredrik och Ingrid Thurings Stiftelse 2017-00309Hjärt-Lungfonden 20150790H.K.H. Kronprinsessan Lovisas Förening för Barnasjukvård 2018-00397Magnus Bergvalls Stiftelse 2017-02113Sällskapet barnavård 4-1562/2018Stiftelsen Frimurare Barnhuset i Stockholm 2017-00348Stiftelsen Samariten 2018-0412
6 · The paper itself

Abstract

backgroundAnxiety and depression are more common in children with obesity than in children of normal weight, but it is unclear whether this association is independent of other known risk factors. Interpretation of results from previous studies is hampered by methodological limitations, including self-reported assessment of anxiety, depression, and anthropometry. The aim of this study was to investigate whether obesity increases the risk of anxiety or depression independently of other risk factors in a large cohort of children and adolescents, using robust measures with regard to exposure and outcome.

methodsChildren aged 6-17 years in the Swedish Childhood Obesity Treatment Register (BORIS, 2005-2015) were included (n = 12,507) and compared with a matched group (sex, year of birth, and area of residence) from the general population (n = 60,063). The main outcome was a diagnosis of anxiety or depression identified through ICD codes or dispensed prescribed medication within 3 years after the end of obesity treatment. Hazard ratios (HRs) with 95% confidence intervals (CIs) from Cox proportional models were adjusted for several known confounders.

resultsObesity remained a significant risk factor for anxiety and depression in children and adolescents after adjusting for Nordic background, neuropsychiatric disorders, family history of anxiety/depression, and socioeconomic status. Girls in the obesity cohort had a 43% higher risk of anxiety and depression compared to girls in the general population (adjusted HR 1.43, 95% CI 1.31-1.57; p < 0.0001). The risk in boys with obesity was similar (adjusted HR 1.33, 95% CI 1.20-1.48; p < 0.0001). In sensitivity analyses, excluding subjects with neuropsychiatric disorders and a family history of anxiety/depression, the estimated risks in individuals with obesity were even higher compared with results from the main analyses (adjusted HR [95% CI]: girls = 1.56 [1.31-1.87], boys = 2.04 [1.64-2.54]).

conclusionsResults from this study support the hypothesis that obesity per se is associated with risk of both anxiety and depression in children and adolescents.

Indexed as

AdolescentAnxietyChildCohort StudiesDepressionFemaleHumansMalePediatric ObesityRisk FactorsSwedenAdolescentsAnxietyChildrenCohort studyDepressionEpidemiologyObesity

Identifiers

PMID32079538
PMCPMC7033939
OpenAlexW3007431409

What OpenQuestion holds

Textmetadata
LicenceCC BY
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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.