Evidence map›Paper›PMID 32079534›Full record

ArticleBMC pregnancy and childbirth2020

Maternal and child-health outcomes in pregnancies following Assisted Reproductive Technology (ART): a prospective cohort study.

Shana Ginar da Silva, Mariângela Freitas da Silveira, Andréa Dâmaso Bertoldi, Marlos Rodrigues Domingues, Iná da Silva Dos Santos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC pregnancy and childbirth, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
7.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Shana Ginar da SilvaPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3° piso, CEP: 96020-220, Bairro Centro, Pelotas, Rio Grande do Sul, Brazil. sginar@gmail.com.ORCID http://orcid.org/0000-0003-1504-6936
Mariângela Freitas da SilveiraPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3° piso, CEP: 96020-220, Bairro Centro, Pelotas, Rio Grande do Sul, Brazil.
Andréa Dâmaso BertoldiPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3° piso, CEP: 96020-220, Bairro Centro, Pelotas, Rio Grande do Sul, Brazil.
Marlos Rodrigues DominguesPostgraduate Program in Physical Education, Federal University of Pelotas, R. Luís de Camões, 625 - Três Vendas, Pelotas, RS, 96055-630, Brazil.
Iná da Silva Dos SantosPostgraduate Program in Epidemiology, Federal University of Pelotas, Rua Marechal Deodoro, 1160 - 3° piso, CEP: 96020-220, Bairro Centro, Pelotas, Rio Grande do Sul, Brazil.
Universidade Federal de Pelotas · BRUniversidade de Passo Fundo · BR

Funding

Wellcome TrustWellcome Trust 095582/z/11/z
6 · The paper itself

Abstract

backgroundStudies comparing the outcome of spontaneous versus assisted reproductive technologies (ART) pregnancies report heterogeneous results. Despite the success of ART to overcome infertility, concern is growing regarding both its safety and its effect on maternal and child health. The objective of this study was to compare maternal and child-health outcomes after ART relative to natural conception.

methodsA population-based birth cohort study was carried out among pregnant women expected to deliver in 2015 in Pelotas, southern Brazil. Maternal outcomes included pregnancy complications and gestational weight gain. Gestational age, weight, intrauterine growth restriction, length and head circumference, and 1-min and 5-min Apgar, as well as health problems at birth and breastfeeding were defined as offspring outcomes. Statistical analyses were performed using linear and logistic regression. G-formula was used to perform mediation analysis.

resultsThe study included 4252 babies born by spontaneously pregnancies and 23 babies born after ART. Adjusted analyses showed that children conceived from ART presented lower means of gestational age (p = 0.001), birth weight (p = 0.002), length (p < 0.001), and head circumference at birth (p = 0.02). However, more than 90% of the effect of ART over these outcomes was mediated by multiple pregnancy.

conclusionOur findings suggest that the possible negative effect on the child-health outcomes is due mainly to the higher incidence of multiple pregnancies and not because of ART. The reasons for the increase in adverse pregnancy outcomes associated with ART singleton pregnancies are still uncertain and warrants further research. Further large-population studies are needed to confirm these results.

Indexed as

AdultBirth WeightBrazilCohort StudiesDelivery, ObstetricFemaleFertilization in VitroFetal Growth RetardationGestational AgeGestational Weight GainHumansInfant, NewbornPregnancyPregnancy ComplicationsPregnancy, MultiplePregnancy OutcomeAssisted reproductive technologyIn vitro fertilizationMaternal-child healthNeonatal outcomesPerinatal health

Identifiers

PMID32079534
PMCPMC7033923
OpenAlexW3011730125

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.