Evidence map›Paper›PMID 32079473›Full record

ArticleRNA biology2020

Characterization of a transcriptional TPP riboswitch in the human pathogen

Francesco Righetti, Solange Lise Materne, John Boss, Hannes Eichner, Emmanuelle Charpentier, Edmund Loh

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in RNA biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. The Involvement of Thiamine Uptake in the Virulence ofPathogens (Basel, Switzerland) · 2022
    Article
  3. Virulence · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 3 countries.

Francesco RighettiDepartment of Microbiology, Tumor- and Cell Biology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0003-4903-2321
Solange Lise MaterneDepartment of Microbiology, Tumor- and Cell Biology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.
John BossDepartment of Microbiology, Tumor- and Cell Biology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-7442-5325
Hannes EichnerDepartment of Microbiology, Tumor- and Cell Biology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0002-1724-420X
Emmanuelle CharpentierMax Planck Unit for the Science of Pathogens, Berlin, Germany.ORCID 0000-0002-0254-0778
Edmund LohDepartment of Microbiology, Tumor- and Cell Biology, BioClinicum, Karolinska University Hospital, Stockholm, Sweden.ORCID 0000-0001-7050-566X
Karolinska University Hospital · SEHumboldt-Universität zu Berlin · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Increasing evidence has demonstrated that regulatory RNA elements such as riboswitches (RS) play a pivotal role in the fine-tuning of bacterial gene expression. In this study, we investigated and characterized a novel transcriptional thiamine pyrophosphate (TPP) RS in the obligate human pathogen

Indexed as

Gene Expression Regulation, BacterialRiboswitchTranscription, GeneticBase SequenceGenes, ReporterHumansMeningococcal InfectionsNeisseria meningitidisNucleic Acid ConformationRNA, BacterialRNA FoldingThiamine PyrophosphateRiboswitchRNA, BacterialThiamine Pyrophosphategene regulationNeisseria meningitidisnon-coding RNApathogenregulatory RNAriboswitchRNATPPvitamin

Identifiers

PMID32079473
PMCPMC7237195
OpenAlexW3006866015

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.