Evidence map›Paper›PMID 32079296›Full record

ReviewInternational journal of molecular sciences2020

Group 2 Innate Lymphoid Cells: Central Players in a Recurring Theme of Repair and Regeneration.

Melina Messing, Sia Cecilia Jan-Abu, Kelly McNagny

Abstract readReview
In one paragraph

Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed.

  1. Review
  2. Article
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  5. Article
  6. Review
  7. Parallel origins and functions of T cells and ILCs.Clinical and experimental immunology · 2023
    Review
  8. Review
  9. Article
  10. Review
  11. Article
  12. Review
  13. Crosstalk between ILC2s and Th2 CD4Journal of immunology research · 2022
    Review
  14. Review
  15. Review
  16. Review
  17. Review
  18. Review
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  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Melina MessingDivision of Experimental Medicine, Faculty of Medicine, University of British Columbia, The Biomedical Research Centre, 2222 Health Sciences Mall, Vancouver, BC V6T 2B9, Canada.
Sia Cecilia Jan-AbuDepartment of Medical Genetics and School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia, The Biomedical Research Centre, 2222 Health Sciences Mall, Vancouver, BC V6T 2B9, Canada.
Kelly McNagnyDepartment of Medical Genetics and School of Biomedical Engineering, Faculty of Applied Science and Faculty of Medicine, University of British Columbia, The Biomedical Research Centre, 2222 Health Sciences Mall, Vancouver, BC V6T 2B9, Canada.

Funding

CIHR PJT-156235
6 · The paper itself

Abstract

Innate lymphoid cells (ILCs) are recently discovered innate counterparts to the well-established T helper cell subsets and are most abundant at barrier surfaces, where they participate in tissue homeostasis and inflammatory responses against invading pathogens. Group 2 innate lymphoid cells (ILC2s) share cytokine and transcription factor expression profiles with type-2 helper T cells and are primarily associated with immune responses against allergens and helminth infections. Emerging data, however, suggests that ILC2s are also key regulators in other inflammatory settings; both in a beneficial context, such as the establishment of neonatal immunity, tissue repair, and homeostasis, and in the context of pathological tissue damage and disease, such as fibrosis development. This review focuses on the interactions of ILC2s with stromal cells, eosinophils, macrophages, and T regulatory cells that are common to the different settings in which type-2 immunity has been explored. We further discuss how an understanding of these interactions can reveal new avenues of therapeutic tissue regeneration, where the role of ILC2s is yet to be fully established.

Indexed as

AnimalsCytokinesFibrosisHumansImmunity, InnateInflammationLungLymphocytesRecurrenceTh2 CellsTranscription FactorsTranscriptomeCytokinesTranscription FactorsInnate lymphoid cells, inflammation, repair, regeneration

Identifiers

PMID32079296
PMCPMC7072936

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.