ArticleJournal of clinical medicine2020
Apical Periodontitis and Diabetes Mellitus Type 2: A Systematic Review and Meta-Analysis.
Article in Journal of clinical medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
23 citing papers in PubMed, 1 synthesis or guideline pooled it, 46 citations in OpenAlex.
- The association between poor glycemic control and apical periodontitis: A systematic review and meta-analysis.Medicina oral, patologia oral y cirugia bucal · 2026Pooled it
- The relationship of apical periodontitis with chronic diseases and smoking habits: an umbrella review.Odontology · 2026Review
- Impact of Endodontic Treatment on CRP Levels in Apical Periodontitis: A Prospective Observational Cohort Study.Journal of clinical medicine · 2025Article
- Impact of calcium hydroxide as an intracanal medicament on postoperative pain in diabetic and non-diabetic patients with symptomatic apical periodontitis and pulp necrosis - a double-blind randomized controlled clinical trial.Journal of clinical and experimental dentistry · 2025Review
- Successful endodontic treatment improves glucose and lipid metabolism: a longitudinal metabolomic study.Journal of translational medicine · 2025Article
- Porphyromonas gingivalis-induced glucose intolerance during periapical lesions requires its LPS throught a Th17 immune response.International journal of oral science · 2025Article
- Comparative Analysis of Root Canal Microbiota in Patients with Diabetes and Systemically Healthy Individuals: A Pilot Next-Generation Sequencing Study.Journal of clinical medicine · 2025Article
- Exploring dentists' perspectives on endodontic treatment for patients with systemic health conditions: A questionnaire-based study.Journal of conservative dentistry and endodontics · 2025Article
- A Two-Way Communication Between Apical Periodontitis and Various Systemic Disorders: A Narrative Review.Cureus · 2025Review
- Connection between oral health and chronic diseases.MedComm · 2025Review
- An exploratory study to understand the relationship between diabetes and various pulpal conditions: An Indian perspective.Journal of conservative dentistry and endodontics · 2024Article
- Apical Periodontitis in Vital and Nonvital Teeth: Clinical and Radiographic Features.Iranian endodontic journal · 2024Review
- Interaction between apical periodontitis and systemic disease (Review).International journal of molecular medicine · 2023Review
- Effect of endodontic treatment on clinical outcome in type 2 diabetic patients with apical periodontitis.Heliyon · 2023Article
- Association between Apical Periodontitis and Chronic Diseases: An Umbrella Review.Iranian endodontic journal · 2023Review
- Poor dental health and risk of pancreatic cancer: a nationwide registry-based cohort study in Sweden, 2009-2016.British journal of cancer · 2022Article
- The impact of apical periodontitis, non-surgical root canal retreatment and periapical surgery on serum inflammatory biomarkers.International endodontic journal · 2022Article
- Association between Endodontic Infection, Its Treatment and Systemic Health: A Narrative Review.Medicina (Kaunas, Lithuania) · 2022Review
- Type 2 diabetes and the clinically normal pulp: An in vitro study.International endodontic journal · 2022Article
- Altered Prevalence of Pulp Diagnoses in Diabetes Mellitus Patients: A Retrospective Study.Journal of endodontics · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveInvestigate if there is an association between apical periodontitis and diabetes mellitus. MATERIAL AND
methodsA bibliographic search was performed on Medline/PubMed, Scopus and Cochrane databases using the keywords apical periodontitis and diabetes mellitus. Published papers written in English and performed on animals or humans were included. Meta-analysis was performed using the OpenMeta (analyst) tool for the statistical analysis. The variables analyzed were the prevalence of Apical Periodontitis (AP) among teeth and patients with Diabetes Mellitus (DM).
resultsOf the total studies found, only 21 met the inclusion criteria. Ten clinical studies on animals, ten studies on humans and a systematic review were included. Meta-analysis shows that the prevalence of teeth with apical periodontitis among patients with diabetes mellitus has an odds ratio of 1.166 corresponding to 507 teeth with AP + DM and 534 teeth with AP without DM. The prevalence of patients with AP and DM shows an odds ratio of 1.552 where 91 patients had AP + DM and 582 patients AP without DM.
conclusionScientific evidence suggests that there could be a common physiopathological factor between apical periodontitis and diabetes mellitus but more prospective studies are needed to investigate the association between these two diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.