Evidence map›Paper›PMID 32079174›Full record

ArticleBrain sciences2020

The Impact of Removal of Ovarian Hormones on Cholinergic Muscarinic Receptors: Examining Prepulse Inhibition and Receptor Binding.

Sarah S Ch'ng, Adam J Walker, Madeleine McCarthy, Thien-Kim Le, Natalie Thomas, Andrew Gibbons, Madhara Udawela, Snezana Kusljic, Brian Dean, Andrea Gogos

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Brain sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Review
  4. Hormones and Cognition.Brain sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 1 country.

Sarah S Ch'ngFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Adam J WalkerFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Madeleine McCarthyFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Thien-Kim LeFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Natalie ThomasFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Andrew GibbonsFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Madhara UdawelaFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Snezana KusljicFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Brian DeanFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
Andrea GogosFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Parkville, VIC 3010, Australia.
The University of Melbourne · AUBarwon Health · AU

Funding

National Health and Medical Research Council CDF ID1108098
6 · The paper itself

Abstract

Ovarian hormones, such as estrogens and progesterone, are known to exert beneficial effects on cognition and some psychiatric disorders. The basis of these effects is not fully understood, but may involve altered cholinergic neurotransmission. This study aimed to investigate how a lack of ovarian hormones would impact muscarinic receptor-induced deficits in prepulse inhibition (PPI) and muscarinic receptor density in several brain regions. Adult female rats were either ovariectomized, to remove the source of ovarian hormones, or left intact (sham-operated). PPI is a measure of sensorimotor gating that is typically impaired in schizophrenia patients, and similar deficits can be induced in rats by administering scopolamine, a muscarinic receptor antagonist. Our results revealed no significant effects of ovariectomy on PPI after saline or scopolamine treatment. Autoradiography was performed to measure cholinergic muscarinic receptor binding density using [

Indexed as

CHRM1femaleovariectomyPPIratschizophrenia

Identifiers

PMID32079174
PMCPMC7071400
OpenAlexW3006022920

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.