Evidence map›Paper›PMID 32079164›Full record

ArticleCancers2020

Autocatalytic Tissue Polymerization Reaction Mechanism in Colorectal Cancer Development and Growth.

Bruce M Boman, Arthur Guetter, Ryan M Boman, Olaf A Runquist

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.3field-weighted citation impact, top 55% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Bruce M BomanCenter for Translational Cancer Research, Helen F. Graham Cancer Center & Research Institute, Newark, DE 19718, USA.
Arthur GuetterDepartment of Mathematics, Hamline University, Saint Paul, MN 55104, USA.
Ryan M BomanDepartment of Materials Science & Engineering, Drexel University, Philadelphia, PA 19104, USA.
Olaf A RunquistDepartment of Chemistry, Hamline University, Saint Paul, MN 55104, USA.
Hamline University · USDrexel University · USThomas Jefferson University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The goal of our study was to measure the kinetics of human colorectal cancer (CRC) development in order to identify aberrant mechanisms in tissue dynamics and processes that contribute to colon tumorigenesis. The kinetics of tumor development were investigated using age-at-tumor diagnosis (adenomas and CRCs) of familial adenomatous coli (FAP) patients and sporadic CRC patients. Plots of age-at-tumor diagnosis data as a function of age showed a distinct sigmoidal-shaped curve that is characteristic of an autocatalytic reaction. Consequently, we performed logistics function analysis and found an excellent fit (

Indexed as

APC geneautocatalytic reactioncancer stem cellscolon cancercrypt fissionfamilial adenomatous polyposislogistic modelnonlinear functiontissue polymerizationtissue renewal

Identifiers

PMID32079164
PMCPMC7072410
OpenAlexW3006167364

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.