Evidence map›Paper›PMID 32078966›Full record

ArticleJournal of anxiety disorders2020

Mediators of youth anxiety outcomes 3 to 12 years after treatment.

Heather B Makover, Philip C Kendall, Thomas Olino, Matthew M Carper, Anne Marie Albano, John Piacentini, Tara Peris, Audra K Langley, Araceli Gonzalez, Golda S Ginsburg and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of anxiety disorders, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Trial
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Heather B MakoverDepartment of Psychology, Temple University, 1301 North 13th Street, Philadelphia, PA, 19122, USA. Electronic address: heather.makover@temple.edu.
Philip C KendallDepartment of Psychology, Temple University, 1301 North 13th Street, Philadelphia, PA, 19122, USA. Electronic address: pkendall@temple.edu.
Thomas OlinoDepartment of Psychology, Temple University, 1301 North 13th Street, Philadelphia, PA, 19122, USA.
Matthew M CarperDepartment of Psychology, Temple University, 1301 North 13th Street, Philadelphia, PA, 19122, USA.
Anne Marie AlbanoColumbia University Clinic for Anxiety and Related Disorders, 1775 Broadway, Suite 601, New York, NY, 10019, USA.
John PiacentiniUCLA Semel Institute, 760 Westwood Blvd, Rm 67-439, Los Angeles, CA, 90024, USA.
Tara PerisUCLA Semel Institute, 760 Westwood Blvd, Rm 67-439, Los Angeles, CA, 90024, USA.
Audra K LangleyUCLA Semel Institute, 760 Westwood Blvd, Rm 67-439, Los Angeles, CA, 90024, USA.
Araceli GonzalezUCLA Semel Institute, 760 Westwood Blvd, Rm 67-439, Los Angeles, CA, 90024, USA.
Golda S GinsburgThe Johns Hopkins University School of Medicine, Division of Child and Adolescent Psychiatry, 550 North Broadway, Suite 202, Baltimore, MD, 21205, USA.
Scott ComptonDuke University Medical Center, Department of Psychiatry and Behavioral Sciences, DUMC Box 3527, Durham, NC, 27710, USA.
Boris BirmaherUniversity of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Dara SakolskyUniversity of Pittsburgh Medical Center, Western Psychiatric Institute and Clinic, 3811 O'Hara Street, Pittsburgh, PA, 15213, USA.
Courtney KeetonThe Johns Hopkins University School of Medicine, Division of Child and Adolescent Psychiatry, 550 North Broadway, Suite 202, Baltimore, MD, 21205, USA.
John WalkupDivision of Child and Adolescent Psychiatry, Department of Psychiatry and Behavioral Sciences at Northwestern University Feinberg School of Medicine, 446 East Ontario, Suite 7-200, Chicago, IL, 60611, USA.

Funding

TRAINING THE SCIENCE OF CHILD MENTAL HEALTH TREATMENTT32MH073517 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI SUMA JACOB, John C. Piacentini · 2006 to 2026
$5.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN · 2002 to 2007
$3.1M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI BIRMAHER, BORIS · 2002 to 2007
$2.7M
Child and Adolescent Anxiety Multisite Study (CAMS)U01MH064107 · NIMH · DUKE UNIVERSITY · PI MARCH, JOHN S · 2002 to 2007
$2.4M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2002 to 2007
$2.2M
Child/Adolescent Anxiety Multimodal Treatment StudyU01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2002 to 2007
$2.1M
5/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064107 · NIMH · DUKE UNIVERSITY · PI COMPTON, SCOTT N · 2010 to 2014
$1.3M
3/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064089 · NIMH · JOHNS HOPKINS UNIVERSITY · PI GINSBURG, GOLDA SUSAN, KEETON, COURTNEY PIERCE · 2010 to 2014
$925k
2/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064003 · NIMH · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI SAKOLSKY, DARA JENNIFER · 2010 to 2014
$659k
4/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH063747 · NIMH · TEMPLE UNIV OF THE COMMONWEALTH · PI KENDALL, PHILIP C · 2010 to 2014
$618k
6/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064088 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI PIACENTINI, JOHN C. · 2010 to 2014
$611k
1/6-Child/Adolescent Anxiety Multimodal Extended Long-Term Study (CAMELS)R01MH064092 · NIMH · COLUMBIA UNIVERSITY HEALTH SCIENCES · PI ALBANO, ANNE MARIE · 2010 to 2014
$574k
NIMH NIH HHS F31 MH105104NIMH NIH HHS R01 MH063747NIMH NIH HHS R01 MH064003NIMH NIH HHS R01 MH064088NIMH NIH HHS R01 MH064089NIMH NIH HHS R01 MH064092NIMH NIH HHS R01 MH064107NIMH NIH HHS T32 MH073517NIMH NIH HHS U01 MH063747NIMH NIH HHS U01 MH064003NIMH NIH HHS U01 MH064088NIMH NIH HHS U01 MH064089NIMH NIH HHS U01 MH064107
6 · The paper itself

Abstract

objectiveTest changes in perceived coping efficacy, negative self-statements, and interpretive biases to threat during treatment as potential mediators of the relationship between randomly assigned treatment conditions and long-term anxiety follow-ups. Age at randomization was also tested as a moderator of mediational relationships.

methodParticipants included 319 youth (ages 7-17) from the Child/Adolescent Multimodal Study (CAMS) who participated in a naturalistic follow-up beginning an average of 6.5 years after the end of the CAMS intervention. The intervention conditions included cognitive behavioral therapy (CBT; Coping Cat), pharmacotherapy (sertraline), combined CBT and sertraline, and pill placebo. Putative mediators were measured four times during the intervention phase. Follow-up consisted of four annual assessments of current anxiety.

resultsReductions on a measure of interpretive bias to threat over the course of the combined condition intervention, as compared to the placebo condition, mediated anxiety outcomes at the first follow-up visit. This mediated effect was not significant for the CBT-only or sertraline-only conditions when compared to the placebo condition. No other significant mediated effects were found for putative mediators. Age did not significantly moderate any mediated effects.

conclusionChanges in youth-reported interpretive biases to threat over the course of combined youth anxiety interventions, as compared to a placebo intervention, may be associated with lower anxiety an average of 6.5 years following treatment.

Indexed as

Cognitive Behavioral TherapyAdaptation, PsychologicalAdolescentAnxietyAnxiety DisordersChildCombined Modality TherapyFemaleFollow-Up StudiesHumansMaleSelective Serotonin Reuptake InhibitorsSertralineTreatment OutcomeSelective Serotonin Reuptake InhibitorsSertralineChildhood anxiety disordersCognitive behavior therapyInterpretive biasesMediatorsTreatment outcomes

Identifiers

PMID32078966
PMCPMC10783175

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.