Evidence map›Paper›PMID 32078788›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Orosomucoid-like 3 Supports Rhinovirus Replication in Human Epithelial Cells.

Yiping Liu, Yury A Bochkov, Jens C Eickhoff, Tianchen Hu, Nicholas A Zumwalde, Jin Wen Tan, Christopher Lopez, Paul S Fichtinger, Thiruchelvi R Reddy, Katherine A Overmyer and 5 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
2.7field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. From gene identifications to therapeutic targets for asthma: Focus on great potentials ofChinese medical journal pulmonary and critical care medicine · 2023
    Review
  3. T-helper 2 mechanisms involved in human rhinovirus infections and asthma.Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology · 2022
    Review
  4. Review
  5. Gene-environment interactions in childhood asthma revisited; expanding the interaction concept.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2022
    Review
  6. Human Rhinovirus Infection of the Respiratory Tract Affects Sphingolipid Synthesis.American journal of respiratory cell and molecular biology · 2022
    Article
  7. A Long Noncoding RNA "lnc"ed to Asthma Genetics.American journal of respiratory cell and molecular biology · 2022
    Article
  8. Review
  9. Review
  10. Orosomucoid-like protein 3, rhinovirus and asthma.World journal of critical care medicine · 2021
    Review
  11. Ceramide and Related Molecules in Viral Infections.International journal of molecular sciences · 2021
    Review
  12. Article
  13. Observational
  14. Article
  15. Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study.Pediatric allergy and immunology : official publication of the European Society of Pediatric Allergy and Immunology · 2020
    Article
  16. Review
  17. Review
  18. Fighting the Common Cold: ORMDL3 in the Crosshairs?American journal of respiratory cell and molecular biology · 2020
    Article
  19. Rhinovirus and Innate Immune Function of Airway Epithelium.Frontiers in cellular and infection microbiology · 2020
    Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors at 3 institutions in 2 countries.

Yiping LiuDepartment of Pediatrics.
Yury A BochkovDepartment of Pediatrics.
Jens C EickhoffDepartment of Biostatistics and Medical Informatics, and.
Tianchen HuDepartment of Pediatrics.
Nicholas A ZumwaldeDepartment of Medical Microbiology and Immunology, and.
Jin Wen TanDepartment of Pediatrics.
Christopher LopezDepartment of Pediatrics.
Paul S FichtingerDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
Thiruchelvi R ReddyMorgridge Institute for Research, Madison, Wisconsin.
Katherine A OvermyerDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin; and.
Jennifer E GumperzDepartment of Medical Microbiology and Immunology, and.
Joshua CoonDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin; and.
Sameer K MathurDepartment of Medicine, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin.
James E GernDepartment of Pediatrics.
Judith A SmithDepartment of Pediatrics.ORCID 0000-0003-4158-8253
University of Wisconsin–Madison · USInstitute for Medical Informatics and Biostatistics · CHMorgridge Institute for Research · US

Funding

Wisconsin Infant Study Cohort (WISC)U19AI104317 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI James E. Gern, CHRISTINE Marie SEROOGY · 2013 to 2026
$22.5M
TR&D 2 Metabolic Labels for Ultraplexed Protein Quantification p. 453P41GM108538 · NIGMS · UNIVERSITY OF WISCONSIN-MADISON · PI COON, JOSHUA J · 2016 to 2025
$13.1M
Mechanisms of iNKT cell anti-viral adjuvancyR01AI136500 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GUMPERZ, JENNY E. · 2018 to 2022
$1.9M
Regulation of human immune function by 17q21 asthma risk polymorphismR21AI121808 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI SMITH, JUDITH ANNE · 2016 to 2017
$421k
NIAID NIH HHS R01 AI136500NIAID NIH HHS R21 AI121808NIAID NIH HHS U19 AI104317NIGMS NIH HHS P41 GM108538
6 · The paper itself

Abstract

Polymorphism at the 17q21 gene locus and wheezing responses to rhinovirus (RV) early in childhood conspire to increase the risk of developing asthma. However, the mechanisms mediating this gene-environment interaction remain unclear. In this study, we investigated the impact of one of the 17q21-encoded genes,

Indexed as

Virus ReplicationA549 CellsAsthmaBronchiCells, CulturedChromosomes, Human, Pair 17Endoplasmic Reticulum StressEpithelial CellsFatty Acids, MonounsaturatedGenetic Predisposition to DiseaseGenotypeHeLa CellsHumansInterferon-betaMembrane ProteinsNasal MucosaFatty Acids, MonounsaturatedInterferon-betaMembrane ProteinsORMDL3 protein, humanRecombinant ProteinsRNA, Small InterferingSerine C-PalmitoyltransferaseSphingolipidsTaurochenodeoxycholic AcidthermozymocidinursodoxicoltaurineasthmaORMDL3rhinovirusSPTunfolded protein response

Identifiers

PMID32078788
PMCPMC7258826
OpenAlexW3007217927

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.