SynthesisAmerican journal of respiratory and critical care medicine2020
Natural History of Cognitive Impairment in Critical Illness Survivors. A Systematic Review.
Synthesis in American journal of respiratory and critical care medicine, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 80 papers, 7 of them syntheses that pooled it.
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Who cites it
80 citing papers in PubMed, 7 syntheses or guidelines pooled it.
- Driving behavior and driving outcomes after acute and critical illness: A systematic review.International journal of nursing studies · 2025Pooled it
- Automated versus non-automated weaning for reducing the duration of mechanical ventilation for critically ill adults and children.The Cochrane database of systematic reviews · 2025Pooled it
- Non-pharmacological interventions to support the cognitive rehabilitation of patients admitted to the intensive care unit: An umbrella review.Nursing in critical care · 2025Pooled it
- Prevalence and incidence of cognitive impairment following acute respiratory distress syndrome of any cause: a systematic review and meta-analysis.Critical care (London, England) · 2025Pooled it
- Pooled it
- COVID-19 associated cognitive impairment: A systematic review.Cortex; a journal devoted to the study of the nervous system and behavior · 2022Pooled it
- Changes in cognitive functioning after COVID-19: A systematic review and meta-analysis.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2022Pooled it
- Acceptability and Fidelity of a Cognitive Rehabilitation Intervention During and After Intensive Care: A Feasibility Evaluation.Nursing in critical care · 2026Trial
- From Intensive Care to Recovery: Feasibility of a Randomised Controlled Study Design Evaluating a Cognitive Rehabilitation Intervention for Critically Ill Patients.Nursing in critical care · 2026Trial
- Profiles of Individuals With Long COVID Reporting Persistent Cognitive Complaints.Archives of clinical neuropsychology : the official journal of the National Academy of Neuropsychologists · 2025Trial
- Objective and subjective cognition in survivors of COVID-19 one year after ICU discharge: the role of demographic, clinical, and emotional factors.Critical care (London, England) · 2023Trial
- Burden of and risk factors for neurological complications in critical illness.Intensive care medicine · 2026Review
- Evaluation for delirium and cognitive function in intensive care unit: reliability and validity of the Jikei Command following Scale in Japan.Acute and critical care · 2026Article
- Inflammatory Biomarkers and Post-Intensive Care Syndrome: A Prospective Cohort Study.Diagnostics (Basel, Switzerland) · 2026Article
- Development of a cognitive rehabilitation intervention to support patients during and after intensive care admission: a stakeholder-informed study.BMC health services research · 2026Article
- Longitudinal Cognitive Recovery After Critical Illness: Trajectories in Sepsis and Non-Sepsis Survivors.Journal of intensive care medicine · 2026Article
- Cognitive Functioning After Circulatory Shock: A Prospective Observational Study.Acta anaesthesiologica Scandinavica · 2026Observational
- Article
- A genomic structural equation modelling study elucidates shared genetic architecture of polygenic traits associated with post-intensive care syndrome.Scientific reports · 2026Article
- Virtual Neuropsychological Assessment After Severe or Critical COVID-19: The NeuroCov Pilot Feasibility Study.Cureus · 2026Article
20 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Long-term cognitive impairment is common among ICU survivors, but its natural history remains unclear. In this systematic review, we report the frequency of cognitive impairment in ICU survivors across various time points after ICU discharge that were extracted from 46 of the 3,350 screened records. Prior studies used a range of cognitive instruments, including subjective assessments (10 studies), single or screening cognitive test such as Mini-Mental State Examination or Trail Making Tests A and B (23 studies), and comprehensive cognitive batteries (26 studies). The mean prevalence of cognitive impairment was higher with objective rather than subjective assessments (54% [95% confidence interval (CI), 51-57%] vs. 35% [95% CI, 29-41%] at 3 months after ICU discharge) and when comprehensive cognitive batteries rather than Mini-Mental State Examination were used (ICU discharge: 61% [95% CI, 38-100%] vs. 36% [95% CI, 15-63%]; 12 months after ICU discharge: 43% [95% CI, 10-78%] vs. 18% [95% CI, 10-20%]). Patients with acute respiratory distress syndrome had higher prevalence of cognitive impairment than mixed ICU patients at ICU discharge (82% [95% CI, 78-86%] vs. 48% [95% CI, 44-52%]). Although some studies repeated tests at more than one time point, the time intervals between tests were arbitrary and dictated by operational limitations of individual studies or chosen cognitive instruments. In summary, the prevalence and temporal trajectory of ICU-related cognitive impairment varies depending on the type of cognitive instrument used and the etiology of critical illness. Future studies should use modern comprehensive batteries to better delineate the natural history of cognitive recovery across ICU patient subgroups and determine which acute illness and treatment factors are associated with better recovery trajectories.
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