Evidence map›Paper›PMID 32078707›Full record

ArticleWorld journal of urology2020

Contrast-enhanced ultrasound with dispersion analysis for the localization of prostate cancer: correlation with radical prostatectomy specimens.

Arnoud W Postema, Maudy C W Gayet, Ruud J G van Sloun, Rogier R Wildeboer, Christophe K Mannaerts, C Dilara Savci-Heijink, Stefan G Schalk, Amir Kajtazovic, Henk van der Poel, Peter F A Mulders and 3 more

2 registry-linked trialsAbstract readMulticenter Study
PubMed Publisher
In one paragraph

Article in World journal of urology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04605276 completednot on this mapstarted 2021, after this paper: background citation

Improving the AI-based Image Analysis Algorithm for 3D Multiparametric Ultrasound for the Detection, Grading and Localization of Prostate Cancer

TypeobservationalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2021 to 2024Enrolled608ConditionsProstate CancerArmsNo intervention
NCT06281769 nacompletednot on this mapstarted 2024, after this paper: background citation

Clinical Validation of Transrectal Multiparametric Ultrasound Imaging Strategy (PCaVision) for the Detection of Clinically Significant Prostate Cancer: a Head-to-head Comparison With the MRI-based Strategy

TypeinterventionalSponsorAcademisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)Ran2024 to 2025Enrolled467ConditionsProstate CancerArms3D multi-parametric ultrasound targeted biopsy pathway using PcaVision, MRI targeted biopsy pathway
3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Review
  6. Review
  7. Article
  8. The combined value of mpUS and mpMRI-TRUS fusion for the diagnosis of clinically significant prostate cancer.Cancer imaging : the official publication of the International Cancer Imaging Society · 2022
    Article
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Arnoud W Postema *Department of Urology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Maudy C W Gayet *Department of Urology, Jeroen Bosch Hospital, Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ, 's Hertogenbosch, The Netherlands. m.gayet@jbz.nl.ORCID http://orcid.org/0000-0002-8321-9301
Ruud J G van SlounDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Rogier R WildeboerDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Christophe K MannaertsDepartment of Urology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
C Dilara Savci-HeijinkDepartment of Pathology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Stefan G SchalkDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Amir KajtazovicDepartment of Urology, Jeroen Bosch Hospital, Jeroen Bosch Ziekenhuis, Henri Dunantstraat 1, 5223 GZ, 's Hertogenbosch, The Netherlands.
Henk van der PoelDepartment of Urology, Netherlands Cancer Institute, Amsterdam, The Netherlands.
Peter F A MuldersDepartment of Urology, Radboud University Medical Center, Nijmegen, The Netherlands.
Harrie P BeerlageDepartment of Urology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.
Massimo MischiDepartment of Electrical Engineering, Eindhoven University of Technology, Eindhoven, The Netherlands.
Hessel WijkstraDepartment of Urology, Amsterdam University Medical Center, University of Amsterdam, Amsterdam, The Netherlands.

Funding

KWF Kankerbestrijding UVA 2013-5941
6 · The paper itself

Abstract

purposeTo determine the value of two-dimensional (2D) contrast-enhanced ultrasound (CEUS) imaging and the additional value of contrast ultrasound dispersion imaging (CUDI) for the localization of clinically significant prostate cancer (csPCa).

methodsIn this multicentre study, subjects scheduled for a radical prostatectomy underwent 2D CEUS imaging preoperatively. CUDI maps were generated from the CEUS recordings. Both CEUS recordings and CUDI maps were scored on the likelihood of presenting csPCa (any Gleason ≥ 4 + 3 and Gleason 3 + 4 larger than 0.5 mL) by five observers and compared to radical prostatectomy histopathology. An automated three-dimensional (3D) fusion protocol was used to match imaging with histopathology. Receiver operator curve (ROC) analysis was performed per observer and imaging modality.

results133 of 216 (62%) patients were included in the final analysis. Average area under the ROC for all five readers for CEUS, CUDI and the combination was 0.78, 0.79 and 0.78, respectively. This yields a sensitivity and specificity of 81 and 64% for CEUS, 83 and 56% for CUDI and 83 and 55% for the combination. Interobserver agreement for CEUS, CUDI and the combination showed kappa values of 0.20, 0.18 and 0.18 respectively.

conclusionThe sensitivity and specificity of 2D CEUS and CUDI for csPCa localization are moderate. Despite compressing CEUS in one image, CUDI showed a similar performance to 2D CEUS. With a sensitivity of 83% at cutoff point 3, it could become a useful imaging procedure, especially with 4D acquisition, improved quantification and combination with other US imaging techniques such as elastography.

Indexed as

ProstatectomyAdultAgedAged, 80 and overContrast MediaCorrelation of DataHumansMaleMiddle AgedProstatic NeoplasmsSensitivity and SpecificityUltrasonographyContrast MediaContrast-enhanced ultrasoundDispersion analysisProstate cancerQuantitative imagingRadical prostatectomy

Identifiers

PMID32078707

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.