ArticleJournal of applied physiology (Bethesda, Md. : 1985)2020
Both hyperthermia and dehydration during physical work in the heat contribute to the risk of acute kidney injury.
Article in Journal of applied physiology (Bethesda, Md. : 1985), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 90 papers, 4 of them syntheses that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
90 citing papers in PubMed, 4 syntheses or guidelines pooled it, 131 citations in OpenAlex.
- First global synthesis of heat-related mental health impacts in children and young people: a systematic review and meta-analysis.International journal of epidemiology · 2026Pooled it
- International migrant workers, heat exposure, and climate change: a systematic review of health risks and protective interventions.BMC global and public health · 2025Pooled it
- Acute Kidney Injury Biomarkers in Marathon Runners: Systematic Review and Meta-Analysis.Medicina (Kaunas, Lithuania) · 2025Pooled it
- Changes in Novel AKI Biomarkers after Exercise. A Systematic Review.International journal of molecular sciences · 2020Pooled it
- Hydrating with a higher-fructose sport drink does not worsen acute kidney injury risk during simulated work-related heat stress.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Trial
- Effect of sodium bicarbonate on performance and markers of kidney and gastrointestinal injury during repeated sprints in the heat.European journal of applied physiology · 2026Trial
- Low-energy cooling strategies modulate biomarkers of kidney injury risk in older adults exposed to very hot and dry heat.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Trial
- Acute sodium bicarbonate supplementation reduces the increase in markers of acute kidney injury during physical work in the heat.European journal of applied physiology · 2025Trial
- 24 h severe fluid restriction increases a biomarker of renal injury in healthy males.European journal of applied physiology · 2025Trial
- Exploring the effects of outdoor physical work in the heat, with or without sodium bicarbonate supplementation, on markers of acute kidney injury.Physiological reports · 2025Trial
- Effect of Ibuprofen on Markers of Acute Kidney Injury, Intestinal Injury, and Endotoxemia after Running in the Heat.Medicine and science in sports and exercise · 2025Trial
- Short-term repeated oral intake of low dose cannabidiol: effects on liver enzyme activity and creatinine concentration during intense exercise.Archives of toxicology · 2025Trial
- Hypohydration produced by high-intensity intermittent running increases biomarkers of renal injury in males.European journal of applied physiology · 2021Trial
- Epidemiology, mechanisms and clinical implications of heat-related kidney disease.Nature reviews. Nephrology · 2026Review
- Water intake mediates cross-sectional associations between urinary kidney injury biomarkers and race in emerging adults.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Article
- Dynamic responses in the human methylome to exertional heat exhaustion, heat injury, and heat stroke.Human genomics · 2026Article
- Impact of heatwave exposure on chronic kidney disease risk among middle-aged and older adults: evidence from the China health and retirement longitudinal study.BMC nephrology · 2026Article
- Validation of the ECTemp™ algorithm in construction workers: a comparison of photoplethysmography smartwatch and chest strap heart rate monitors.Environmental research communications · 2026Article
- Fluid balance, kidney function, and acute kidney injury risk in healthy men and women during simulated work-related heat stress.Journal of applied physiology (Bethesda, Md. : 1985) · 2026Article
30 more citing papers are in PubMed but not listed here.
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Authors and funding
6 authors at 2 institutions in 1 country.
Funding
Abstract
Occupational heat stress increases the risk of acute kidney injury (AKI) and kidney disease. This study tested the hypothesis that attenuating the magnitude of hyperthermia (i.e., increase in core temperature) and/or dehydration during prolonged physical work in the heat attenuates increases in AKI biomarkers. Thirteen healthy adults (3 women, 23 ± 2 yr) exercised for 2 h in a 39.7 ± 0.6°C, 32 ± 3% relative-humidity environmental chamber. In four trials, subjects received water to remain euhydrated (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.