Evidence map›Paper›PMID 32078385›Full record

ArticleHypertension (Dallas, Tex. : 1979)2020

From Rags to Riches: Moving Beyond RAG1 in Studies of Hypertension.

Meena S Madhur, Annet Kirabo, Tomasz J Guzik, David G Harrison

Abstract readEditorialComment
In one paragraph

Article in Hypertension (Dallas, Tex. : 1979), 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Article
  4. The role of T cells in vascular aging, hypertension, and atherosclerosis.American journal of physiology. Heart and circulatory physiology · 2024
    Review
  5. Immune and inflammatory mechanisms in hypertension.Nature reviews. Cardiology · 2024
    Review
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  7. Review
  8. Article
  9. Review
  10. Review
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

4 authors.

Meena S MadhurFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.S.M., A.K., D.G.H.).
Annet KiraboFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.S.M., A.K., D.G.H.).
Tomasz J GuzikInstitute of Cardiovascular and Medical Sciences, BHF Glasgow Cardiovascular Research Centre, University of Glasgow, United Kingdom (T.J.G.).
David G HarrisonFrom the Division of Clinical Pharmacology, Department of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.S.M., A.K., D.G.H.).

Funding

The Role of Inflammation in Cardiovascular DiseaseP01HL129941 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNSTEIN, KENNETH E · 2016 to 2020
$12.4M
Mechanisms of Immune Activation in HypertensionR35HL140016 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI HARRISON, DAVID G · 2018 to 2024
$5.3M
ENaC regulation and its role in blood pressure homeostasisR01HL147818 · NHLBI · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI Annet Kirabo, Thomas R Kleyman · 2019 to 2026
$4.6M
Immunophenotyping of Human Hypertension Using Single Cell Multiplex Mass Cytometry to Identify Novel Therapeutic TargetsDP2HL137166 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI MADHUR, MEENAKSHI SWAMINATHAN · 2016 to 2021
$2.8M
Vanderbilt Hypertension and Blood Pressure Regulation ProgramT32HL144446 · NHLBI · VANDERBILT UNIVERSITY · PI HARRISON, DAVID G · 2019 to 2023
$1.7M
Role of Salt, Isoketal-modified Proteins and Dendritic Cells in HypertensionK01HL130497 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI KIRABO, ANNET · 2016 to 2020
$803k
British Heart Foundation RE/13/5/30177NHLBI NIH HHS DP2 HL137166NHLBI NIH HHS K01 HL130497NHLBI NIH HHS P01 HL129941NHLBI NIH HHS R01 HL147818NHLBI NIH HHS R35 HL140016NHLBI NIH HHS T32 HL144446
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Angiotensin IIHypertensionAnimalsHomeodomain ProteinsLaboratoriesMiceMice, KnockoutPhenotypeAngiotensin IIHomeodomain Proteins

Identifiers

PMID32078385
PMCPMC7067673

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.