Trial reportCirculation2020
The Prognostic Significance of Quantitative Myocardial Perfusion: An Artificial Intelligence-Based Approach Using Perfusion Mapping.
Trial report in Circulation, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04805814 (The Clinical Utility Of Cardiac Magnetic Resonance Imaging in Patients With Angina But No Obstructive Coronary Disease), which is not on this map. Cited by 118 papers, 6 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
The Clinical Utility Of Cardiac Magnetic Resonance Imaging in Patients With Angina But No Obstructive Coronary Disease (CorCMR): A Diagnostic Study And Nested Randomised Trial
Who cites it
118 citing papers in PubMed, 6 syntheses or guidelines pooled it, 196 citations in OpenAlex.
- PRIME 2.0: Proposed Requirements for Cardiovascular Imaging-Related Multimodal-AI Evaluation: An Updated Checklist.JACC. Cardiovascular imaging · 2026Guideline
- Prognostic Value of Stress Perfusion Cardiac MRI in Cardiovascular Disease: A Systematic Review and Meta-Analysis of the Effects of the Scanner, Stress Agent, and Analysis Technique.Radiology. Cardiothoracic imaging · 2024Pooled it
- Diagnostic and Prognostic Value of Stress Cardiovascular Magnetic Resonance Imaging in Patients With Known or Suspected Coronary Artery Disease: A Systematic Review and Meta-analysis.JAMA cardiology · 2023Pooled it
- The Role of Artificial Intelligence in Predicting Outcomes by Cardiovascular Magnetic Resonance: A Comprehensive Systematic Review.Medicina (Kaunas, Lithuania) · 2022Pooled it
- Coronary flow reserve and cardiovascular outcomes: a systematic review and meta-analysis.European heart journal · 2022Pooled it
- Society for cardiovascular magnetic resonance expert consensus statement on quantitative myocardial perfusion cardiovascular magnetic resonance imaging.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceGuideline
- Accelerated stress CMR for the detection of significant coronary artery disease: a prospective randomized diagnostic accuracy study.European heart journal. Cardiovascular Imaging · 2026Trial
- Zibotentan in Microvascular Angina: A Randomized, Placebo-Controlled, Crossover Trial.Circulation · 2024Trial
- Randomized Placebo-Controlled Trial to Evaluate Effects of Eplerenone on Myocardial Perfusion and Function Among Persons With Human Immunodeficiency Virus (HIV)-Results From the MIRACLE HIV Study.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2023Trial
- Diagnosis and Nursing Intervention of Gynecological Ovarian Endometriosis with Magnetic Resonance Imaging under Artificial Intelligence Algorithm.Computational intelligence and neuroscience · 2022Trial
- Randomized controlled trial of vericiguat in patients with coronary microvascular dysfunction causing stable chest pain (V-COM): study protocol for a randomized control trial.Journal of cardiovascular magnetic resonance : official journal of the Society for Cardiovascular Magnetic ResonanceTrial
- Feasibility of 12-lead ECG reconstruction at rest and during adenosine stress perfusion inside a 3-Tesla MR scanner.The international journal of cardiovascular imaging · 2026Article
- Impact of rate-pressure product correction of myocardial blood flow on the prognostic relevance in patients with heart failure.European heart journal. Cardiovascular Imaging · 2026Article
- A Novel Demography-Based Approach to Define Patient-Specific Outflow Boundary Conditions in CT-Based FFR Computations.Annals of biomedical engineering · 2026Article
- Role of a Heart Center for Women in the Prevention and Diagnosis of Atherosclerotic Cardiovascular Disease in Women.Journal of the American Heart Association · 2026Review
- Myocardial perfusion reserve is low in heart transplant patients and is related to exercise capacity.Clinical physiology and functional imaging · 2026Article
- Prognosis and risk stratification in first-presentation myocardial infarction with nonobstructive coronary arteries using stress cardiac MRI.Insights into imaging · 2026Article
- Abnormal myocardial perfusion reserve and myocardial infarction determine cardiovascular outcomes in type 2 diabetes mellitus.European heart journal. Cardiovascular Imaging · 2026Article
- Artificial intelligence in cardiology in the current era: a narrative review.Cardiovascular diagnosis and therapy · 2026Review
- Review
58 more citing papers are in PubMed but not listed here.
Corrections and comments
- Commented on by
Authors and funding
18 authors at 7 institutions in 2 countries.
Funding
Abstract
backgroundMyocardial perfusion reflects the macro- and microvascular coronary circulation. Recent quantitation developments using cardiovascular magnetic resonance perfusion permit automated measurement clinically. We explored the prognostic significance of stress myocardial blood flow (MBF) and myocardial perfusion reserve (MPR, the ratio of stress to rest MBF).
methodsA 2-center study of patients with both suspected and known coronary artery disease referred clinically for perfusion assessment. Image analysis was performed automatically using a novel artificial intelligence approach deriving global and regional stress and rest MBF and MPR. Cox proportional hazard models adjusting for comorbidities and cardiovascular magnetic resonance parameters sought associations of stress MBF and MPR with death and major adverse cardiovascular events (MACE), including myocardial infarction, stroke, heart failure hospitalization, late (>90 day) revascularization, and death.
resultsA total of 1049 patients were included with a median follow-up of 605 (interquartile range, 464-814) days. There were 42 (4.0%) deaths and 188 MACE in 174 (16.6%) patients. Stress MBF and MPR were independently associated with both death and MACE. For each 1 mL·g
conclusionsIn patients with known or suspected coronary artery disease, reduced MBF and MPR measured automatically inline using artificial intelligence quantification of cardiovascular magnetic resonance perfusion mapping provides a strong, independent predictor of adverse cardiovascular outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.