ArticleCirculation. Arrhythmia and electrophysiology2020
Genetic Susceptibility for Atrial Fibrillation in Patients Undergoing Atrial Fibrillation Ablation.
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Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.
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30citing papers in PubMed
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30 citing papers in PubMed, 50 citations in OpenAlex.
- Association of genetic risk and outcomes in patients with atrial fibrillation: interactions with early rhythm control in the EAST-AFNET4 trial.Cardiovascular research · 2023Trial
- Reduced left atrial cardiomyocyte PITX2 and elevated circulating BMP10 predict atrial fibrillation after ablation.JCI insight · 2020Trial
- Impact of Downregulated Inflammation via the IL6R Asp358Ala Variant on Atrial Fibrillation Recurrence Following Ablation.JACC. Advances · 2026Article
- Multiple 4q25 risk variants impair calcium homeostasis and compromise left atrial function.Cardiovascular research · 2026Article
- Cardiac Surgery and Postoperative Atrial Fibrillation: The Role of Cancer.Medicina (Kaunas, Lithuania) · 2025Review
- Unravelling Sex Disparities in the Pathophysiology of Atrial Fibrillation: Review of the Current Evidence.Journal of cardiovascular electrophysiology · 2025Review
- Genome-Wide Association Study of Atrial Fibrillation Recurrence After Radiofrequency Catheter Ablation in a Japanese Population.Journal of cardiovascular electrophysiology · 2025Article
- Review
- Comparative analysis of recurrence predictors and outcomes for atrial tachyarrhythmia following atrial fibrillation ablation: high-power short-duration vs. conventional pulmonary vein isolation.Heart and vessels · 2025Article
- Comparing Phenotypes for Acute and Long-Term Response to Atrial Fibrillation Ablation Using Machine Learning.Circulation. Arrhythmia and electrophysiology · 2025Article
- Treating Cardiovascular Disorders with Personalized Medicine.Cardiovascular & hematological disorders drug targets · 2025Review
- Innovative approaches to atrial fibrillation prediction: should polygenic scores and machine learning be implemented in clinical practice?Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Review
- Longer and better lives for patients with atrial fibrillation: the 9th AFNET/EHRA consensus conference.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024Article
- [Genetic basis of atrial fibrillation-on the road to precision medicine].Herzschrittmachertherapie & Elektrophysiologie · 2024Review
- An effective prediction model based on XGBoost for the 12-month recurrence of AF patients after RFA.BMC cardiovascular disorders · 2023Article
- Polygenic risk scores are associated with atrial electrophysiologic substrate abnormalities and outcomes after atrial fibrillation catheter ablation.Heart rhythm · 2023Article
- Advances in basic and translational research in atrial fibrillation.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023Review
- Genome and atrial fibrillation.Journal of arrhythmia · 2023Review
- The spatiotemporal electrogram dispersion ablation targeting rotors is more effective for elderly patients than non-elderly population.Journal of arrhythmia · 2023Article
- Identifying Suitable Targets for Alzheimer's Disease and Other Eight Common Neurological Disorders Using the Human Plasma Proteome: A Mendelian Randomization Study.Journal of Alzheimer's disease reports · 2023Article
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Authors and funding
49 authors at 17 institutions in 6 countries.
M Benjamin ShoemakerDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Daniela HusserHeart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).
Carolina RoselliProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).
Meelad Al JazairiDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).
Jonathan ChrispinDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.C., H.C.).
Michael KühneUniversity Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Benjamin NeumannDepartment of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
Stacey KnightIntermountain Heart Institute, Intermountain Medical Center, Murray (S. Knight, V.J.).
Han SunDepartment of Quantitative Health Sciences (H.S., J.B.), Lerner Research Institute, Cleveland Clinic, OH.
Sanghamitra MohantyTexas Cardiac Arrhythmia Institute, Austin, TX (S.M., A.N.).
Christian ShafferDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Sébastien ThériaultPopulation Health Research Institute, McMaster University, Hamilton, ON, Canada (S.T., D.C.).
Lauren Lee RinkeDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Joylene E SilandDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).
Diane M CrawfordDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Laura UeberhamHeart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).
Omeed ZardkoohiDepartments of Cardiovascular Medicine and Molecular Cardiology, Heart and Vascular Institute (O.Z., M.C.), Lerner Research Institute, Cleveland Clinic, OH.
Petra BüttnerHeart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).
Bastiaan GeelhoedDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).
Steffen BlumUniversity Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Stefanie AeschbacherUniversity Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Jonathan D SmithDepartment of Cellular and Molecular Medicine (J.D.S.), Lerner Research Institute, Cleveland Clinic, OH.
David R Van WagonerDepartment of Molecular Cardiology (D.R.V.W.), Lerner Research Institute, Cleveland Clinic, OH.
Rebecca FreudlingDepartment of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
Martina Müller-NurasyidInstitute of Genetic Epidemiology, Helmholtz Zentrum München, Neuherberg (R.F., M.M.-N.).
Jay MontgomeryDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Zachary YonedaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Quinn WellsDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Tariq IssaDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Peter WeekeDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Victoria JacobsIntermountain Heart Institute, Intermountain Medical Center, Murray (S. Knight, V.J.).
Isabelle C Van GelderDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).
Gerhard HindricksHeart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).
John BarnardDepartment of Quantitative Health Sciences (H.S., J.B.), Lerner Research Institute, Cleveland Clinic, OH.
Hugh CalkinsDivision of Cardiology, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD (J.C., H.C.).
Dawood DarbarDivision of Cardiology, Department of Medicine, University of Illinois Health, Chicago (D.D.).
Greg MichaudDepartment of Medicine, Vanderbilt University Medical Center, Nashville, TN (M.B.S., C.S., L.L.R., D.M.C., J.M., Z.Y., Q.W., T.I., P.W., G.M.).
Stefan KääbDepartment of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
Patrick EllinorProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).
Andrea NataleTexas Cardiac Arrhythmia Institute, Austin, TX (S.M., A.N.).
Mina ChungDepartments of Cardiovascular Medicine and Molecular Cardiology, Heart and Vascular Institute (O.Z., M.C.), Lerner Research Institute, Cleveland Clinic, OH.
Saman NazarianDivision of Cardiology, University of Pennsylvania Perelman School of Medicine, Philadelphia (S.N.).
Michael J CutlerIntermountain Heart Institute, Intermountain Medical Center, Murray, UT (M.J.C.).
Moritz F SinnerDepartment of Medicine, University Hospital Munich, Ludwig Maximilians University of Munich, Germany (B.N., R.F., S. Kääb, M.F.S.).
David ConenUniversity Hospital Basel, Switzerland (M.K., S.B., S.A., D.C.).
Michiel RienstraDepartment of Cardiology, University of Groningen, University Medical Center Groningen, the Netherlands (M.A.J., J.E.S., B.G., I.C.V.G., M.R.).
Andreas BollmannHeart Center Leipzig, Department of Electrophysiology, Leipzig Heart Institute, University of Leipzig, Germany (D.H., L.U., P.B., G.H., A.B.).
Dan M RodenAnimal, Dairy, and Veterinary Sciences, Utah State University, Logan (D.M.R.).
Steven LubitzProgram in Medical and Population Genetics, The Broad Institute of MIT and Harvard, Program in Medical and Population Genetics, Cambridge, MA (C.R., P.E., S.L.).
Vanderbilt University Medical Center · USCleveland Clinic Lerner College of Medicine · USLeipzig Heart Institute · DEUniversity Medical Center Groningen · NLUniversity Hospital of Basel · CHBroad Institute · USDell Children's Medical Center of Central Texas · USGerman Centre for Cardiovascular Research · DEHelmholtz Zentrum München · DEIntermountain Medical Center · USJohns Hopkins University · USLudwig-Maximilians-Universität München · DEPopulation Health Research Institute · CAUniversity of Illinois Chicago · USUniversity of Pennsylvania · USUniversity of Utah · USUtah State University · US
Funding
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7MThe Vanderbilt Institute for Clinical and Translational Research (VICTR)UL1TR000445 · NCATS · VANDERBILT UNIVERSITY MEDICAL CENTER · PI BERNARD, GORDON RAPHAEL · 2012 to 2016
$41.4MClinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5MCHARGE Consortium: Omics Discovery for CVD and Aging PhenotypesR01HL105756 · NHLBI · UNIVERSITY OF WASHINGTON · PI Bruce M Psaty, NICHOLAS L SMITH · 2011 to 2026
$9.5MFunctional Genomics of Atrial Fibrillation in Human AtriaR01HL111314 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2012 to 2019
$6.1MGenomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3MGenetics of Atrial FibrillationR01HL090620 · NHLBI · CLEVELAND CLINIC LERNER COM-CWRU · PI BARNARD, JOHN, CHUNG, MINA KAY · 2008 to 2012
$2.9MDeciphering the genetic mechanisms of atrial fibrillationR01HL138737 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2017 to 2020
$2.6MImplications of Intra-Myocardial Fat Deposition upon Propensity for Malignant ArrhythmiaR01HL142893 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN, TRAYANOVA, NATALIA A. · 2018 to 2021
$2.5MTraining Program in Personalized Cardiovascular Medicine (TPIPCVM)T32HL139439 · NHLBI · UNIVERSITY OF ILLINOIS AT CHICAGO · PI DARBAR, DAWOOD · 2018 to 2022
$2.1MANCILLARY STUDY OF SUBSTRATE AND INTERVENTION MECHANISMS FOR MALIGNANT ARRHYTHMIAR01HL116280 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI NAZARIAN, SAMAN · 2013 to 2016
$1.2MAtrial Fibrillation Susceptibility Due to Genetic Variation at Chromosome 4q25K23HL127704 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI SHOEMAKER, MOORE BENJAMIN · 2015 to 2019
$869kNCATS NIH HHS UL1 TR000445NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024989NHLBI NIH HHS K23 HL127704NHLBI NIH HHS R01 HL090620NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL111314NHLBI NIH HHS R01 HL116280NHLBI NIH HHS R01 HL138737NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL142893NHLBI NIH HHS T32 HL139439
Abstract
backgroundAblation is a widely used therapy for atrial fibrillation (AF); however, arrhythmia recurrence and repeat procedures are common. Studies examining surrogate markers of genetic susceptibility to AF, such as family history and individual AF susceptibility alleles, suggest these may be associated with recurrence outcomes. Accordingly, the aim of this study was to test the association between AF genetic susceptibility and recurrence after ablation using a comprehensive polygenic risk score for AF.
methodsTen centers from the AF Genetics Consortium identified patients who had undergone de novo AF ablation. AF genetic susceptibility was measured using a previously described polygenic risk score (N=929 single-nucleotide polymorphisms) and tested for an association with clinical characteristics and time-to-recurrence with a 3 month blanking period. Recurrence was defined as >30 seconds of AF, atrial flutter, or atrial tachycardia. Multivariable analysis adjusted for age, sex, height, body mass index, persistent AF, hypertension, coronary disease, left atrial size, left ventricular ejection fraction, and year of ablation.
resultsFour thousand two hundred seventy-six patients were eligible for analysis of baseline characteristics and 3259 for recurrence outcomes. The overall arrhythmia recurrence rate between 3 and 12 months was 44% (1443/3259). Patients with higher AF genetic susceptibility were younger (
conclusionsHigher AF genetic susceptibility was associated with younger age and fewer clinical risk factors but not recurrence. Arrhythmia recurrence after AF ablation may represent a genetically different phenotype compared to AF susceptibility.
Indexed as
Catheter AblationGenetic Predisposition to DiseasePolymorphism, Single NucleotideAgedAtrial FibrillationBody Surface Potential MappingFemaleFollow-Up StudiesHumansMaleMiddle AgedMultifactorial InheritancePreoperative PeriodPrognosisProspective StudiesRecurrenceatrial fibrillationgeneticsgenetic variationphenotypepulmonary veins
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