Evidence map›Paper›PMID 32078361›Full record

ArticleCirculation. Arrhythmia and electrophysiology2020

Initial Precipitants and Recurrence of Atrial Fibrillation.

Elizabeth Y Wang, Olivia L Hulme, Shaan Khurshid, Lu-Chen Weng, Seung Hoan Choi, Allan J Walkey, Jeffrey M Ashburner, David D McManus, Daniel E Singer, Steven J Atlas and 4 more

Open access · bronzeAbstract readMulticenter Study
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
44citing papers in PubMed, 4 pooled it
6.0field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

44 citing papers in PubMed, 4 syntheses or guidelines pooled it, 73 citations in OpenAlex.

  1. Pooled it
  2. Guideline
  3. Guideline
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Review
  9. Article
  10. Review
  11. Review
  12. Article
  13. Article
  14. Review
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Spotlight on the 2024 ESC/EACTS management of atrial fibrillation guidelines: 10 novel key aspects.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2024
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 6 institutions in 1 country.

Elizabeth Y WangCardiovascular Research Center (E.Y.W., O.L.H., S.K., L.-C.W., P.T.E.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Olivia L HulmeCardiovascular Research Center (E.Y.W., O.L.H., S.K., L.-C.W., P.T.E.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Shaan KhurshidCardiovascular Research Center (E.Y.W., O.L.H., S.K., L.-C.W., P.T.E.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Lu-Chen WengCardiovascular Research Center (E.Y.W., O.L.H., S.K., L.-C.W., P.T.E.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Seung Hoan ChoiCardiovascular Disease Initiative, The Broad Institute of Harvard and MIT, Cambridge, MA (S.K., L.-C.W., S.H.C., P.T.E., S.A.L.).
Allan J WalkeyBoston University School of Medicine (A.J.W.), Harvard Medical School, MA.
Jeffrey M AshburnerDivision of General Internal Medicine (J.M.A., D.E.S., S.J.A.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
David D McManusDepartment of Medicine, University of Massachusetts Medical School, Worcester (D.D.M.).
Daniel E SingerDivision of General Internal Medicine (J.M.A., D.E.S., S.J.A.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Steven J AtlasDivision of General Internal Medicine (J.M.A., D.E.S., S.J.A.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Emelia J BenjaminDepartment of Medicine, Sections of Preventive Medicine and Cardiovascular Medicine (E.J.B.), Harvard Medical School, MA.
Patrick T EllinorCardiovascular Research Center (E.Y.W., O.L.H., S.K., L.-C.W., P.T.E.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Ludovic TrinquartDepartment of Biostatistics (L.T.), Boston University School of Public Health, MA.
Steven A LubitzDivision of Cardiology (S.K., S.A.L.), Cardiac Arrhythmia Service, Massachusetts General Hospital, Boston.
Broad Institute · USHarvard University · USBoston University · USMassachusetts General Hospital · USSt. Elizabeth Hospital in Enumclaw · USUniversity of Massachusetts Chan Medical School · US

Funding

The Center for Advancing Point of Care in Heart, Lung, Blood and Sleep DiseasesU54HL143541 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI BRYAN O BUCHHOLZ, Nathaniel Scott Hafer · 2018 to 2026
$141.0M
IDENTIFICATION OF COMMON GENETIC VARIANTS FOR ATRIAL FIBRILLATION AND PR INTERVALR01HL092577 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2009 to 2025
$20.6M
Research Training and Education Core (Core D) P50HL120163 · NHLBI · AMERICAN HEART ASSOCIATION · PI SRIVASTAVA, SANJAY · 2013 to 2017
$20.1M
MULTIDISCIPLINARY RESEARCH TRAINING IN CARDIOLOGYT32HL007208 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI Patrick Thomas Ellinor, David E Sosnovik · 1985 to 2026
$16.1M
Genomics of Cardiac ArrhythmiasR01HL139731 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI ELLINOR, PATRICK THOMAS · 2018 to 2022
$3.3M
Detecting bleeding events using EHRs for prediction in AfibR01HL137794 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., YU, HONG · 2018 to 2021
$3.3M
Systematic Assessment of Geriatric Elements in Atrial Fibrillation (SAGE-AF)R01HL126911 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI MCMANUS, DAVID D., SACZYNSKI, JANE STEELE · 2016 to 2019
$3.2M
Community Surveillance of Coronary Heart DiseaseR01HL135219 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI GOLDBERG, ROBERT JOEL, YU, HONG · 2017 to 2020
$3.2M
AFGen Consortium: Atrial Fibrillation Genomics to Functional AnalysesR01HL128914 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., ELLINOR, PATRICK THOMAS · 2015 to 2018
$3.1M
Smartwatch Monitoring for Atrial Fibrillation After StrokeR01HL137734 · NHLBI · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI CHON, KI H, MCMANUS, DAVID D. · 2018 to 2021
$3.1M
FHS-NEXT - Framingham Novel EXam using TechnologyR01HL141434 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BENJAMIN, EMELIA J., MCMANUS, DAVID D. · 2019 to 2022
$2.5M
Automated detection and prediction of atrial fibrillation during sepsisR01HL136660 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI WALKEY, ALLAN J. · 2017 to 2020
$2.2M
Doris Duke Charitable Foundation 2017039NHLBI NIH HHS K24 HL105780NHLBI NIH HHS P50 HL120163NHLBI NIH HHS R01 HL092577NHLBI NIH HHS R01 HL104156NHLBI NIH HHS R01 HL126911NHLBI NIH HHS R01 HL128914NHLBI NIH HHS R01 HL135219NHLBI NIH HHS R01 HL136660NHLBI NIH HHS R01 HL137734NHLBI NIH HHS R01 HL137794NHLBI NIH HHS R01 HL139731NHLBI NIH HHS R01 HL141434NHLBI NIH HHS T32 HL007208NHLBI NIH HHS U54 HL143541NIA NIH HHS R21 AG060529
6 · The paper itself

Abstract

backgroundAtrial fibrillation (AF) may occur after an acute precipitant and subsequently resolve. Management guidelines for AF in these settings are unclear as the risk of recurrent AF and related morbidity is poorly understood. We examined the relations between acute precipitants of AF and long-term recurrence of AF in a clinical setting.

methodsFrom a multi-institutional longitudinal electronic medical record database, we identified patients with newly diagnosed AF between 2000 and 2014. We developed algorithms to identify acute AF precipitants (surgery, sepsis, pneumonia, pneumothorax, respiratory failure, myocardial infarction, thyrotoxicosis, alcohol, pericarditis, pulmonary embolism, and myocarditis). We assessed risks of AF recurrence in individuals with and without a precipitant and the relations between AF recurrence and heart failure, stroke, and mortality.

resultsAmong 10 723 patients with newly diagnosed AF (67.9±9.9 years, 41% women), 19% had an acute AF precipitant, the most common of which were cardiac surgery (22%), pneumonia (20%), and noncardiothoracic surgery (15%). The cumulative incidence of AF recurrence at 5 years was 41% among individuals with a precipitant compared with 52% in those without a precipitant (adjusted hazard ratio [HR], 0.75 [95% CI, 0.69-0.81];

conclusionsAF after an acute precipitant frequently recurs, although the risk of recurrence is lower than among individuals without an acute precipitant. Recurrence is associated with substantial long-term morbidity and mortality. Future studies should address surveillance and management after newly diagnosed AF in the setting of an acute precipitant.

Indexed as

AlgorithmsAdultAgedAged, 80 and overAtrial FibrillationFemaleFollow-Up StudiesHeart FailureHumansIncidenceMaleMiddle AgedProspective StudiesRecurrenceRisk AssessmentRisk Factorsatrial fibrillationheart failuremortalityrisk factorstroke

Identifiers

PMID32078361
PMCPMC7141776
OpenAlexW3006659751

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.