Evidence map›Paper›PMID 32078336›Full record

ArticleAmerican journal of respiratory cell and molecular biology2020

Adoptive T-Cell Transfer to Treat Lymphangioleiomyomatosis.

Fei Han, Emilia R Dellacecca, Levi W Barse, Cormac Cosgrove, Steven W Henning, Christian M Ankney, Dinesh Jaishankar, Alexander Yemelyanov, Vera P Krymskaya, Daniel F Dilling and 1 more

Open access · greenAbstract read
In one paragraph

Article in American journal of respiratory cell and molecular biology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 16 citations in OpenAlex.

  1. Modulation of infiltrating CD206The European respiratory journal · 2025
    Article
  2. Novel treatment strategies for lymphangioleiomyomatosis: a narrative review.European respiratory review : an official journal of the European Respiratory Society · 2025
    Review
  3. Review
  4. Plasmacytoid Dendritic Cells: Bring a Glimmer of Hope for Patients with Lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2024
    Article
  5. Article
  6. Article
  7. Review
  8. Lymphangioleiomyomatosis: a metastatic lung disease.American journal of physiology. Cell physiology · 2023
    Review
  9. Article
  10. Review
  11. Article
  12. Tuberous sclerosis complex for the pulmonologist.European respiratory review : an official journal of the European Respiratory Society · 2021
    Article
  13. "T"eeing Up A Novel Therapy for Lymphangioleiomyomatosis.American journal of respiratory cell and molecular biology · 2020
    Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Fei HanLurie Comprehensive Cancer Center.
Emilia R DellaceccaLurie Comprehensive Cancer Center.ORCID 0000-0001-9031-2240
Levi W BarseDepartment of Pharmacology, and.
Cormac CosgroveLurie Comprehensive Cancer Center.ORCID 0000-0001-7856-2984
Steven W HenningLurie Comprehensive Cancer Center.
Christian M AnkneyDepartment of Microbiology and Immunology, Loyola University Chicago, Maywood, Illinois.
Dinesh JaishankarLurie Comprehensive Cancer Center.ORCID 0000-0001-7906-176X
Alexander YemelyanovDivision of Pulmonary and Critical Care, Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, Illinois.
Vera P KrymskayaDepartment of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania; and.ORCID 0000-0002-0584-4486
Daniel F DillingDepartment of Medicine, Loyola University Medical Center, Maywood, Illinois.ORCID 0000-0002-9723-510X
I Caroline Le PooleLurie Comprehensive Cancer Center.ORCID 0000-0001-6853-4007
Robert H. Lurie Comprehensive Cancer Center of Northwestern UniversityNorthwestern University · USLoyola University Chicago · USLoyola University Medical Center · USUniversity of Pennsylvania · US

Funding

Lymphangiogenesis in Pulmonary Lymphangioleiomyomatosis (LAM)R01HL131626 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2016 to 2019
$2.6M
mTOR signaling in lung homeostasis, aging and diseaseR01HL151467 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P · 2020 to 2023
$2.0M
Urokinase-type plasminogen activator (uPA) in pathogenesis of lymphangioleiomyomatosis (LAM)R01HL141462 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI KRYMSKAYA, VERA P, STEPANOVA, VICTORIA · 2019 to 2022
$1.8M
NHLBI NIH HHS R01 HL131626NHLBI NIH HHS R01 HL141462NHLBI NIH HHS R01 HL151467
6 · The paper itself

Abstract

Patients with lymphangioleiomyomatosis (LAM) develop pulmonary cysts associated with neoplastic, smooth muscle-like cells that feature neuroendocrine cell markers. The disease preferentially affects premenopausal women. Existing therapeutics do not cure LAM. As gp100 is a diagnostic marker expressed by LAM lesions, we proposed to target this immunogenic glycoprotein using TCR transgenic T cells. To reproduce the genetic mutations underlying LAM, we cultured

Indexed as

Immunotherapy, AdoptiveAnimalsCell LineCell Line, TumorCoculture TechniquesGene Knockout Techniquesgp100 Melanoma AntigenImmunocompetenceKidney NeoplasmsLymphangioleiomyomatosisMaleMelanomaMiceMice, Mutant StrainsMice, SCIDMice, Transgenicgp100 Melanoma AntigenLyst protein, mousePdcd1 protein, mouseProgrammed Cell Death 1 ReceptorReceptors, Antigen, T-CellRecombinant ProteinsTsc2 protein, mouseTuberous Sclerosis Complex 2 ProteinVesicular Transport Proteinsadoptive T cell transfergp100lymphangioleiomyomatosisT cell receptor

Identifiers

PMID32078336
PMCPMC7710336
OpenAlexW3007226444

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.