Evidence map›Paper›PMID 32078279›Full record

ArticleJournal of psychiatry & neuroscience : JPN2020

Hippocampal and parahippocampal volumes vary by sex and traumatic life events in children

Amy S. Badura-Brack, Mackenzie S. Mills, Christine M. Embury, Maya M. Khanna, Alicia Klanecky Earl, Julia M. Stephen, Yu-Ping Wang, Vince D. Calhoun, Tony W. Wilson

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of psychiatry & neuroscience : JPN, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
0.6field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
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  7. Subclinical Anxiety and Posttraumatic Stress Influence Cortical Thinning During Adolescence.Journal of the American Academy of Child and Adolescent Psychiatry · 2021
    Article
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 6 institutions in 1 country.

Amy S. Badura-BrackFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Mackenzie S. MillsFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Christine M. EmburyFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Maya M. KhannaFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Alicia Klanecky EarlFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Julia M. StephenFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Yu-Ping WangFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Vince D. CalhounFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Tony W. WilsonFrom the Department of Psychological Science, Creighton University, Omaha, NE (Badura-Brack, Mills, Khanna, Klanecky Earl); the Department of Neurological Sciences, University of Nebraska Medical Center, Omaha, NE (Embury, Wilson); the Department of Psychology, University of Nebraska at Omaha, Omaha, NE (Embury); the Mind Research Network, Albuquerque, NM (Stephen, Calhoun); and the Department of Biomedical Engineering, Tulane University, New Orleans, LA (Wang).
Tulane University · USUniversity of Nebraska at Omaha · USCreighton University · USMind Research Network · USNebraska Medical Center · USUniversity of Nebraska Medical Center · US

Funding

DEVELOPMENTAL MULTIMODAL IMAGING OF NEUROCOGNITIVE DYNAMICS (DEV-MIND)R01MH121101 · NIMH · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI WILSON, TONY W · 2019 to 2023
$5.8M
NIMH NIH HHS R01 MH121101
6 · The paper itself

Abstract

Background: Childhood trauma is reliably associated with smaller hippocampal volume in adults; however, this finding has not been shown in children, and even less is known about how sex and trauma interact to affect limbic structural development in children. Methods: Typically developing children aged 9 to 15 years who completed a trauma history questionnaire and structural T1-weighted MRI were included in this study (n = 172; 85 female, 87 male). All children who reported 4 or more traumas (n = 36) composed the high trauma group, and all children who reported 3 or fewer traumas (n = 136) composed the low trauma group. Using multivariate analysis of covariance, we compared FreeSurfer-derived structural MRI volumes (normalized by total intracranial volume) of the amygdalar, hippocampal and parahippocampal regions by sex and trauma level, controlling for age and study site. Results: We found a significant sex × trauma interaction, such that girls with high trauma had greater volumes than boys with high trauma. Follow-up analyses indicated significantly increased volumes for girls and generally decreased volumes for boys, specifically in the hippocampal and parahippocampalregions for the high trauma group; we observed no sex differences in the low trauma group. We noted no interaction effect for the amygdalae. Limitations: We assessed a community sample and did not include a clinical sample. We did not collect data about the ages at which children experienced trauma. Conclusion: Results revealed that psychological trauma affects brain development differently in girls and boys. These findings need to be followed longitudinally to elucidate how structural differences progress and contribute to well-known sex disparities in psychopathology.

Indexed as

AdolescentAdverse Childhood ExperiencesAmygdalaBereavementChildExposure to ViolenceFemaleHippocampusHumansMagnetic Resonance ImagingMaleOrgan SizeParahippocampal GyrusPsychological TraumaSex FactorsViolence

Identifiers

PMID32078279
PMCPMC7828931
OpenAlexW3012573648

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.