SynthesisDigestive diseases and sciences2021
Esophagogastric Junction Morphology on Hill's Classification Predicts Gastroesophageal Reflux with Good Accuracy and Consistency.
Synthesis in Digestive diseases and sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Sliding hiatal hernia detected by transnasal esophagogastroscopy is associated with poorer treatment response in reflux-associated globus sensation.Scientific reports · 2026Article
- DGCNet: a clinical knowledge-driven model for the segmentation of reflux esophagitis in endoscopic images.Gastroenterology report · 2026Article
- Revolutionizing upper gastrointestinal disease diagnosis: The transformative role of artificial intelligence in endoscopy.World journal of gastrointestinal endoscopy · 2025Review
- Efficacy of the Bridge Dry Swallowing Exercise for Refractory Gastroesophageal Reflux Disease.Internal medicine (Tokyo, Japan) · 2025Article
- Constructing an artificial intelligence-assisted system for the assessment of gastroesophageal valve function based on the hill classification (with video).BMC medical informatics and decision making · 2025Article
- Prospective Evaluation of Real-Time Artificial Intelligence for the Hill Classification of the Gastroesophageal Junction.United European gastroenterology journal · 2025Article
- Phase concept: Novel dynamic endoscopic assessment of intramural antireflux mechanisms (with video).Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society · 2025Article
- Established and Novel Methods to Assess GERD: An Update.Visceral medicine · 2024Review
- Value of endoscopic grading of gastroesophageal flap valve in gastroesophageal reflux disease.Surgical endoscopy · 2024Article
- Review
- Functional lumen imaging probe topography identifies patients with normal acid exposure and esophageal hypervigilance amongst proton-pump inhibitor non-responders.Surgical endoscopy · 2024Article
- Predicting reflux symptom recurrence: The impact of gastroesophageal junction indicators and body mass index among outpatients.Experimental and therapeutic medicine · 2023Article
- Using deep learning to assess the function of gastroesophageal flap valve according to the Hill classification system.Annals of medicine · 2023Article
- Clinical Endoscopic and Histologic Findings of a Long-Term Follow-Up (10.7 Years) After Roux-en-Y Laparoscopic Gastric Bypass: a Prospective Study.Obesity surgery · 2022Article
- Correlation between gastroesophageal flap valve abnormality and novel parameters in patients with gastroesophageal reflux disease symptoms by the lyon consensus.Scientific reports · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionHill's classification provides a reproducible endoscopic grading system for esophagogastric junction morphology and competence, specifically whether the gastroesophageal flap valve (GEFV) is normal (grade I/II) or abnormal (grades III/IV). However, it is not routinely used in clinical practice. We report a systematic review and meta-analysis to determine association between abnormal GEFV and gastroesophageal reflux disorder (GERD).
methodsA comprehensive literature search of MEDLINE and Scopus databases was conducted to identify studies that reported the association between abnormal GEFV and GERD. The search and quality assessment were performed independently by two authors. Fixed- and random-effects meta-analyses were conducted using symptomatic GERD and erosive esophagitis as outcomes.
resultsA total of 11 studies met inclusion criteria that included a total of 5054 patients. In the general population, patients with abnormal GEFV had greater risk of symptomatic GERD compared to patients with a normal GEFV (risk ratio [RR] 1.88, 95% CI 1.57-2.24). Further, in patients with symptomatic GERD, patients with abnormal GEFV had greater risk of erosive esophagitis compared to patients with normal GEFV (RR 2.17, 95% CI 1.40-3.36). Finally, the specificity of abnormal GEFV for symptomatic GERD was 73.3% (95% CI 69.3-77.0%) and 75.7% (95% CI 65.9-83.4%) for erosive esophagitis in symptomatic GERD.
conclusionOur systematic review and meta-analysis showed consistent association between abnormal GEFV indicated by Hill's classification III/IV and symptomatic GERD and erosive esophagitis. Our recommendation is to include Hill's classification in routine endoscopy reports and workup for GERD.
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