Evidence map›Paper›PMID 32078054›Full record

ArticleBasic research in cardiology2020

Inhibition of Na

Steffen Pabel, Shakil Ahmad, Petros Tirilomis, Thea Stehle, Julian Mustroph, Maria Knierim, Nataliya Dybkova, Philipp Bengel, Andreas Holzamer, Michael Hilker and 4 more

Open access · hybridAbstract read
In one paragraph

Article in Basic research in cardiology, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
4.2field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Article
  5. MOG1medRxiv : the preprint server for health sciences · 2025
    Article
  6. Article
  7. Article
  8. Article
  9. Blocking NaBMC cardiovascular disorders · 2024
    Article
  10. Molecular Study of Sudden Cardiac Death.International journal of molecular sciences · 2024
    Article
  11. NaInternational journal of molecular sciences · 2024
    Article
  12. Patient-specific induced pluripotent stem cell properties implicate CaPhilosophical transactions of the Royal Society of London. Series B, Biological sciences · 2023
    Article
  13. Molecular and Functional Relevance of NaInternational journal of molecular sciences · 2023
    Article
  14. GBiomedicines · 2023
    Article
  15. Article
  16. Inhibition of NaRSC medicinal chemistry · 2022
    Review
  17. Article
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 2 institutions in 1 country.

Steffen PabelDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Shakil AhmadDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Petros TirilomisClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Thea StehleDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Julian MustrophDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Maria KnierimClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Nataliya DybkovaClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Philipp BengelClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Andreas HolzamerDepartment of Cardiothoracic Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Michael HilkerDepartment of Cardiothoracic Surgery, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Katrin Streckfuss-BömekeClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Gerd HasenfussClinic for Cardiology and Pneumology, Georg-August University Göttingen, Robert Koch Str. 40, 37075, Göttingen, Germany.
Lars S MaierDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany.
Samuel SossallaDepartment of Internal Medicine II, University Medical Center Regensburg, Franz-Josef-Strauß-Allee 11, 93053, Regensburg, Germany. samuel.sossalla@ukr.de.ORCID 0000-0001-8034-2673
University Hospital Regensburg · DEGerman Centre for Cardiovascular Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pharmacologic approaches for the treatment of atrial arrhythmias are limited due to side effects and low efficacy. Thus, the identification of new antiarrhythmic targets is of clinical interest. Recent genome studies suggested an involvement of SCN10A sodium channels (Na

Indexed as

Action PotentialsAgedAniline CompoundsAnimalsAnti-Arrhythmia AgentsArrhythmias, CardiacCells, CulturedDisease Models, AnimalFemaleFuransHeart RateHumansMaleMice, KnockoutMiddle AgedMyocytes, Cardiac6-amino-5-(2,3,5-trichlorophenyl)pyridine-2-carboxylic acid methylamideA 803467Aniline CompoundsAnti-Arrhythmia AgentsFuransNAV1.8 Voltage-Gated Sodium ChannelPicolinic AcidsSCN10A protein, humanScn10a protein, mouseSodium Channel BlockersAntiarrhythmic drugsAtrial arrhythmiasLate sodium currentNa+ channel

Identifiers

PMID32078054
PMCPMC7033079
OpenAlexW3008404646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.