ArticleeLife2020
The hippocampus encodes delay and value information during delay-discounting decision making.
Article in eLife, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 24 citations in OpenAlex.
- Habit and the hippocampus: Model-based spatial representations without outcome-sensitive control.bioRxiv : the preprint server for biology · 2026Article
- Transsynaptic neural circuit mapping of ventral hippocampus motivational control systems.Brain structure & function · 2026Article
- Article
- Persistent sensory processing and behavioral atypicalities in a mouse model of neonatal encephalopathy.bioRxiv : the preprint server for biology · 2026Article
- Task-dependent neural dynamics in hippocampal CA1 during auditory and visual perceptual decision-making in rats.Brain structure & function · 2026Article
- GATE: Adaptive learning with working memory by information gating in multi-lamellar hippocampal formation.PLoS computational biology · 2026Article
- A framework for uniting space and time in the mind and brain.Frontiers in cognition · 2025Article
- The role of the human hippocampus in decision-making under uncertainty.Nature human behaviour · 2024Article
- The Hippocampus Contributes to Temporal Discounting When Delays and Rewards Are Experienced in the Moment.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Habitual intake of fat and sugar is associated with poorer memory and greater impulsivity in humans.PloS one · 2023Article
- Navigation task and action space drive the emergence of egocentric and allocentric spatial representations.PLoS computational biology · 2022Article
- Complementary roles of serotonergic and cholinergic systems in decisions about when to act.Current biology : CB · 2022Article
- Hippocampal neurogenesis promotes preference for future rewards.Molecular psychiatry · 2021Article
- Article
- The Architecture of Human Memory: Insights from Human Single-Neuron Recordings.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2021Review
- Article
- Assessing Impulsivity in Humans and Rodents: Taking the Translational Road.Frontiers in behavioral neuroscience · 2021Review
- Brain mechanisms of temporal processing in impulsivity: Relevance to attention-deficit hyperactivity disorder.Brain and neuroscience advancesReview
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 3 institutions in 1 country.
Funding
Abstract
The hippocampus, a region critical for memory and spatial navigation, has been implicated in delay discounting, the decline in subjective reward value when a delay is imposed. However, how delay information is encoded in the hippocampus is poorly understood. Here, we recorded from CA1 of mice performing a delay-discounting decision-making task, where delay lengths, delay positions, and reward amounts were changed across sessions, and identified subpopulations of CA1 neurons that increased or decreased their firing rate during long delays. The activity of both delay-active and -suppressed cells reflected delay length, delay position, and reward amount; but manipulating reward amount differentially impacted the two populations, suggesting distinct roles in the valuation process. Further, genetic deletion of the N-methyl-D-aspartate (NMDA) receptor in hippocampal pyramidal cells impaired delay-discount behavior and diminished delay-dependent activity in CA1. Our results suggest that distinct subclasses of hippocampal neurons concertedly support delay-discounting decisions in a manner that is dependent on NMDA receptor function.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.