Evidence map›Paper›PMID 32077289›Full record

ArticleOrganic letters2020

Concise Formal Synthesis of the Pseudopterosins via Anionic Oxy-Cope/Transannular Michael Addition Cascade.

Vincenzo Ramella, Philipp C Roosen, Christopher D Vanderwal

Abstract read
In one paragraph

Article in Organic letters, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. A Convergent Total Synthesis of (+)-Ineleganolide.Journal of the American Chemical Society · 2023
    Article
  2. Article
  3. Article
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors.

Vincenzo RamellaDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States.
Philipp C RoosenDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States.
Christopher D VanderwalDepartment of Chemistry, 1102 Natural Sciences II, University of California, Irvine, California 92697-2025, United States.ORCID 0000-0001-7218-4521

Funding

Hit-to-Lead Development of the Kalihinol Scaffold for Malaria TreatmentR01AI138139 · NIAID · UNIVERSITY OF CALIFORNIA-IRVINE · PI BEN MAMOUN, CHOUKRI, LE ROCH, KARINE GAELLE · 2018 to 2022
$3.6M
NIAID NIH HHS R01 AI138139
6 · The paper itself

Abstract

An anionic oxy-Cope/transannular Michael addition cascade converts a spirocyclic architecture-readily available by Diels-Alder cycloaddition-into the hydrophenalene carbon skeleton of the pseudopterosin aglycones. Oxidation of the resulting cyclohexenone ring to the phenol that is characteristic of the targets completes a short formal synthesis.

Indexed as

AnionsCycloaddition ReactionCyclohexanonesDiterpenesGlycosidesMolecular StructurePhenolsStereoisomerismAnionsCyclohexanonesDiterpenesGlycosidesPhenolspseudopterosins

Identifiers

PMID32077289
PMCPMC7278522

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.